2.4.1.62: ganglioside galactosyltransferase This is an abbreviated version! For detailed information about ganglioside galactosyltransferase, go to the full flat file .
Reaction
UDP-alpha-D-galactose +
an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide =
UDP +
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Synonyms B3GALT4, beta 1,3-galactosyltransferase, beta3Gal-T, ceramide galactosyltransferase, ceramide galactosyltransferase UGT8, CGT, CgtB 11168, cgtBOH HS:10, cgtBOH4384, GA1/GM1/GD1b synthase, Gal-T2, galactosyltransferase, uridine diphosphogalactose-ceramide, GALT, GalT-3, GM1-synthase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-ceramide galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, UDP-galactose:GM2 ganglioside beta1-3 galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase
ECTree
Disease
Disease on EC 2.4.1.62 - ganglioside galactosyltransferase
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Adenoma
Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy.
Alzheimer Disease
DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.
Breast Neoplasms
Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.
Breast Neoplasms
Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.
Breast Neoplasms
Molecular basis of incomplete O-glycan synthesis in MCF-7 breast cancer cells: putative role of MUC6 in Tn antigen expression.
Carcinoma
Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
Carcinoma
Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy.
Cholestasis
Changes in GM1 ganglioside content and localization in cholestatic rat liver.
Colonic Neoplasms
beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas.
Colorectal Neoplasms
Clinical correlation of B7-H3 and B3GALT4 with the prognosis of colorectal cancer.
Demyelinating Diseases
Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase.
Leukodystrophy, Globoid Cell
Glycosylceramide synthesis in the developing spinal cord and kidney of the twitcher mouse, an enzymatically authentic model of human Krabbe disease.
Neoplasm Metastasis
Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.
Neoplasm Metastasis
Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.
Neoplasms
Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
Neoplasms
Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.
Pancreatic Neoplasms
Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue.
Paralysis
Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase.
Sarcoma
Absence of a specific ganglioside galactosyltransferase in mouse cells transformed by murine sarcoma virus.
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