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2.4.1.50: procollagen galactosyltransferase

This is an abbreviated version!
For detailed information about procollagen galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.50

Reaction

UDP-alpha-D-galactose
+
[procollagen]-(5R)-5-hydroxy-L-lysine
=
UDP
+
[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine

Synonyms

B3GALT6, beta(1-O)galactosyltransferase, beta1,O galactosyltransferase GLT25D1, beta3GalT6, COLGALT1, COLGALT2, collagen beta(1-O)galactosyltransferase, collagen galactosyltransferase, collagen galactosyltransferase GLT25D1, collagen hydroxylysyl galactosyltransferase, collagen hydroxylysyl glycosylsyltransferase, galactosyltransferase II, galactosyltransferase, uridine diphosphogalactose-collagen, GLT25D1, GLT25D2, glycosyl transferase25domain 1, hydroxylysine galactosyltransferase, hydroxylysyl galactosyltransferase, LH3, LH3/PLOD3, lysyl hydroxylase 3, multifunctional procollagen lysine hydroxylase and glycosyltransferase, P3H1, PLOD2, PLOD3, procollagen lysyl hydroxylase 2, prolyl 3-hydroxylase 1, UDP galactose-collagen galactosyltransferase, UDPgalactose:5-hydroxylysine-collagen galactosyltransferase, uridine diphosphogalactose-collagen galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.50 procollagen galactosyltransferase

Reference

Reference on EC 2.4.1.50 - procollagen galactosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kivirikko, K.I.; Myllylä, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Cavia porcellus, Gallus gallus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Bosmann, H.B.; Eylar, E.H.
Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen
Biochem. Biophys. Res. Commun.
33
340-346
1968
Cavia porcellus
Manually annotated by BRENDA team
Barber, A.J.; Jamieson, G.A.
Characterization of membrane-bound collagen galactosyltransferase of human blood platelets
Biochim. Biophys. Acta
252
546-552
1971
Homo sapiens
Manually annotated by BRENDA team
Risteli, L.; Myllylä, R.; Kivirikko, K.I.
Partial purification and characterization of collagen galactosyltransferase from chick embryos
Biochem. J.
155
145-153
1976
Gallus gallus
Manually annotated by BRENDA team
Carnicero, H.H.; Adamany, A.M.; Englard, S.
Collagen glucosyl- and galactosyltransferases of cultured human fetal lung fibroblasts
Arch. Biochem. Biophys.
210
678-690
1981
Homo sapiens
Manually annotated by BRENDA team
Risteli, L.; Myllylä, R.; Kivirikko, K.I.
Affinity chromatography of collagen glycosyltransferases on collagen linked to agarose
Eur. J. Biochem.
67
197-202
1976
Gallus gallus
Manually annotated by BRENDA team
Risteli, L.
Further characterization of collagen galactosyltransferase from chick embryos
Biochem. J.
169
189-196
1978
Gallus gallus
Manually annotated by BRENDA team
Myllylä, R.; Risteli, L.; Kivirikko, K.I.
Assay of collagen-galactosyltransferase and collagen-glucosyltransferase activities and preliminary characterization of enzymic reactions with transferases from chick-embryo cartilage
Eur. J. Biochem.
52
401-410
1975
Gallus gallus
Manually annotated by BRENDA team
Salo, A.M.; Cox, H.; Farndon, P.; Moss, C.; Grindulis, H.; Risteli, M.; Robins, S.P.; Myllylae, R.
A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene
Am. J. Hum. Genet.
83
495-503
2008
Homo sapiens
Manually annotated by BRENDA team
Risteli, M.; Ruotsalainen, H.; Salo, A.M.; Sormunen, R.; Sipilae, L.; Baker, N.L.; Lamande, S.R.; Vimpari-Kauppinen, L.; Myllylae, R.
Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix
J. Biol. Chem.
284
28204-28211
2009
Mus musculus, Homo sapiens (O60568)
Manually annotated by BRENDA team
Wang, C.; Kovanen, V.; Raudasoja, P.; Eskelinen, S.; Pospiech, H.; Myllylae, R.
The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
J. Cell. Mol. Med.
13
508-521
2009
Homo sapiens
Manually annotated by BRENDA team
Schegg, B.; Huelsmeier, A.J.; Rutschmann, C.; Maag, C.; Hennet, T.
Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
Mol. Cell. Biol.
29
943-952
2009
Gallus gallus, Homo sapiens (Q8IYK4), Homo sapiens (Q8NBJ5), Homo sapiens
Manually annotated by BRENDA team
Liefhebber, J.; Punt, S.; Spaan, W.; van Leeuwen, H.
The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein
BMC Cell Biol.
11
33
2010
Homo sapiens (Q8NBJ5), Homo sapiens
Manually annotated by BRENDA team
Perrin-Tricaud, C.; Rutschmann, C.; Hennet, T.
Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1
PLoS ONE
6
e29390
2011
Homo sapiens (Q8NBJ5), Homo sapiens
Manually annotated by BRENDA team
Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Mol. Cancer Res.
11
456-466
2013
Homo sapiens (O00469)
Manually annotated by BRENDA team
Malfait,F.; Kariminejad, A.; Van Damme,T.; Gauche, C.; Syx, D.; Merhi-Soussi, F.; Gulberti, S.; Symoens, S.; Vanhauwaert, S.; Willaert, A.; Bozorgmehr, B.; Kariminejad, M.H.; Ebrahimiadib, N.; Hausser, I.; Huysseune, A.; Fournel-Gigleux, S.; De Paepe, A.
Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-Syndrome-like connective tissue disorder
Am. J. Hum. Genet.
92
935-945
2013
Homo sapiens
Manually annotated by BRENDA team
Ishikawa, Y.; Baechinger, H.P.
An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1-cartilage-associated protein-cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro
J. Biol. Chem.
288
31437-31446
2013
Gallus gallus
Manually annotated by BRENDA team
Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin
PLoS ONE
9
e113498
2014
Homo sapiens
Manually annotated by BRENDA team
Webster, J.A.; Yang, Z.; Kim, Y.H.; Loo, D.; Mosa, R.M.; Li, H.; Chen, C.
Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation
Biosci. Rep.
37
BSR20170105
2017
Homo sapiens (Q8NBJ5), Homo sapiens, Mus musculus (Q8K297)
Manually annotated by BRENDA team
Baumann, S.; Hennet, T.
Collagen accumulation in osteosarcoma cells lacking GLT25D1 collagen galactosyltransferase
J. Biol. Chem.
291
18514-18524
2016
Homo sapiens (Q8IYK4), Homo sapiens (Q8NBJ5)
Manually annotated by BRENDA team
Scietti, L.; Chiapparino, A.; De Giorgi, F.; Fumagalli, M.; Khoriauli, L.; Nergadze, S.; Basu, S.; Olieric, V.; Cucca, L.; Banushi, B.; Profumo, A.; Giulotto, E.; Gissen, P.; Forneris, F.
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Nat. Commun.
9
3163
2018
Homo sapiens (O60568)
Manually annotated by BRENDA team