2.4.1.40: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.40

2.4.1.40

acetoacetate

acetobutylicum

succinyl-coenzyme

3-oxoacids

2.8.3.5

solventogenesis

acetoacetyl-coenzyme

synthesis

Reaction

glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose

glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-D-galactose

Synonyms

A transferase, A-transferase, ABO, ABO(H) blood group A glycosyltransferase, alpha-(1,3)-N-acetylgalactosaminyltransferase, alpha-3-N-acetylgalactosaminyltransferase, bacterial GTA, BgtA, blood group A glycosyltransferase, blood group A glycosyltransferase 2, blood-group substance A-dependent acetylgalactosaminyltransferase, blood-group substance alpha-acetyltransferase, cis-AB-transferase, fucosylgalactose acetylgalactosaminyltransferase, glycosyltransferases A, GTA, histo-blood group A acetylgalactosaminyltransferase, histo-blood group A glycosyltransferase (Fucalpha1-2Galalpha1-3-N-acetylgalactosaminyltransferase), histo-blood group A transferase, histo-blood group ABO system transferase, More, UDP-GalNAc:Fucalpha1-2Galalpha1-3-N-acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.40 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase

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Results	in table
34	AA Sequence
1	Application
1	CAS Registry Number
18	Cloned(Commentary)
13	Crystallization (Commentary)
74	Disease/ Diagnostics
2	General Information
3	General Stability
17	Inhibitors
3	Ki Value [mM]
36	KM Value [mM]
1	Localization
6	Metals/Ions
7	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
50	Organism
4	Pathway
119	PDB ID
9	pH Optimum
2	Posttranslational Modification
20	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
49	Reference
50	Source Tissue
5	Specific Activity [micromol/min/mg]
8	Storage Stability
56	Substrates and Products (Substrate)
6	Subunits
33	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.4.1.40 - glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase

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UDP-Gal + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3

Homo sapiens

489121, 489123

UDP-N-acetyl-alpha-D-galactosamine + 2'-fucosyllactose

UDP + N-acetyl-alpha-D-galactosaminyl-(1,3)-[2'-fucosyllactose]

Rattus norvegicus

Q9ET32

658843

UDP-N-acetyl-alpha-D-galactosamine + alpha-Fuc-(1->2)-beta-D-Gal-(CH2)7CH3

UDP + alpha-D-GalNAc-(1->3)-[alpha-Fuc-(1->2)]-beta-D-Gal-(CH2)7CH3

Homo sapiens

P16422

756890

UDP-N-acetyl-alpha-D-galactosamine + alpha-Fuc-(1->2)-beta-D-Gal-(CH2)7CH3

UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-Fuc-(1->2)]-beta-D-Gal-(CH2)7CH3

Homo sapiens

P16442

756888

UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose

UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-beta-D-glucose

Rattus norvegicus

Q9ET32

658843

UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose

UDP + N-acetyl-alpha-D-galactosaminyl-2'-fucosyllactose

3 entries

UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R

UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R

2 entries

UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3

Homo sapiens

P16442

41% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3

674703

UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3

Homo sapiens

P16442

79% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3

674703

UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3

UDP + alpha-D-GalNAc-(1,3)-[alpha-(Fucp-(1,2)])-beta-D-Galp-O(CH2)7CH3

Homo sapiens

P16442

674703

UDP-N-acetyl-D-galactosamine + asialo-porcine submaxillary mucin of A-negative blood-type

UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[asialo-porcine submaxillary mucin of A-negative blood-type]

Sus scrofa

489165

UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose

UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose

9 entries

UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose

UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose

3 entries

UDP-N-acetyl-D-galactosamine + H type 3-Sp-biotin

UDP + ?

Rattus norvegicus

Q9ET32

H type 3-Sp-biotin is the preferred substrate

658843

UDP-N-acetyl-D-galactosamine + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3

UDP + alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3

2 entries

UDP-N-acetyl-D-galactosamine + lacto-N-fucopentaose I

UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[lacto-N-fucopentaose I]

Homo sapiens

i.e. Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc

489161, 489162, 489166

UDP-N-acetyl-D-glucosamine + L-fucosyl-alpha-1,2-beta-glucosyl-O(CH2)7CH3

UDP + N-acetyl-alpha-D-glucosaminyl-1,3-[alpha-L-fucosyl-1,2]-beta-D-glucosyl-O(CH2)7CH3

2 entries

UDP-N-acetylgalactosamine + octyl 3-O-methyl-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside

UDP + N-acetyl-alpha-D-galactosamine-1,3-[3-O-methyl-alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3

Homo sapiens

489119

UDP-N-acetylgalactosamine + octyl 4-O-methyl-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside

UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[4-O-methyl-alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3

Homo sapiens

489119

UDP-N-acetylgalactosamine + octyl alpha-L-xylo-hexopyranosyl-(1-2)-beta-D-galactopyranoside

UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-xylo-hexopyranosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3

Homo sapiens

489119

UDP-N-acetylgalactosamine + octyl beta-D-arabinopyranosyl-(1-2)-beta-D-galactopyranoside

UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[beta-D-arabinopyranosyl-1,2-beta-D-galactosyl-O(CH2)7CH3]

Homo sapiens

489119

additional information

9 entries