2.4.1.37: fucosylgalactoside 3-alpha-galactosyltransferase

This is an abbreviated version!
For detailed information about fucosylgalactoside 3-alpha-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

ABO(H) blood group B alpha-(1->3)-galactosyltransferase, ABO(H) blood group B alpha-1,3-galactosyltransferase, ABO(H) blood group B glycosyltransferase, ABO(H) blood-group glycosyltransferase B, alpha(1-3)galactosyltransferase, alpha-(1,3)-galactosyltransferase, alpha-(1-3)-galactosyltransferase, alpha-(1->3)-galactosyltransferase, alphaGal-T1, B glycosyltransferase, B transferase, blood group alpha-(1-3)-galactosyltransferase, blood group B alpha-(1,3)-galactosyltransferase, blood group B galactosyltransferase, blood group B glycosyltransferase, blood group B glycosyltransferase GTB, blood group B-glycosyltransferase, blood-group substance B-dependent galactosyltransferase, cis-AB-transferase, glycoprotein-fucosylgalactoside alpha-galactosyltransferase, glycosyltransferases B, GTB, histo-blood group ABO system transferase, histo-blood group B enzyme, histo-blood group B transferase, histo-blood substance B-dependent galactosyltransferase, More, UDP-galactose:fucoside alpha1,3-galactosyltransferase, UDP-galactose:O-alpha-L-fucosyl(1-2)D-galactose alpha-D-galactosyltransferase, UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase, [blood group substance] alpha-galactosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase

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Results	in table
3	Activating Compound
87	AA Sequence
1	CAS Registry Number
24	Cloned(Commentary)
17	Crystallization (Commentary)
12	Disease/ Diagnostics
3	General Information
1	General Stability
12	IC50 Value
33	Inhibitors
7	Ki Value [mM]
91	KM Value [mM]
8	Localization
25	Metals/Ions
3	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
73	Organism
4	Pathway
121	PDB ID
16	pH Optimum
1	pI Value
50	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
67	Reference
29	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
112	Substrates and Products (Substrate)
5	Subunits
69	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Stability [°C]
52	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.37 - fucosylgalactoside 3-alpha-galactosyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-alpha-D-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-R

2 entries

UDP-D-galactose + fucosylated Skp1 protein

UDP + alpha-D-galactosyl(1-3)-fucosyl-Skp1 protein

Dictyostelium discoideum

-

-

659358

-

-

?

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactose

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactose

2 entries

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-R

Homo sapiens

P16442

-

693025

-

-

?

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R

2 entries

UDP-galactose + alpha-L-fucosyl-(1-2)-D-galactosyl-O-R

UDP + alpha-D-galactosyl-(1-3)-[alpha-L-fucosyl-(1-2)]-D-galactosyl-O-R

Homo sapiens

P16442

H-antigen disaccharide

659283

-

-

?

UDP-galactose + blood group antigen

UDP + alpha-D-galactosyl-blood group antigen

Homo sapiens

-

GTB catalyzes the transfer of galactose from UDP-Gal to the C3 position of the terminal galactose of H antigen acceptors

703919

-

-

?

UDP-galactose + blood group antigen H

UDP + alpha-D-galactosyl-blood group antigen H

2 entries

UDP-galactose + glycoprotein alpha-L-fucosyl-1,2-D-galactose

UDP + glycoprotein alpha-D-galactosyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose

2 entries

additional information

?

-

2 entries

UDP-alpha-D-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-R

Homo sapiens

-

-

735779, 736611

-

-

?

UDP-alpha-D-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-R

Homo sapiens

P16442

-

735391, 736196, 736489, 736492

-

-

?

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactose

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactose

Homo sapiens

-

-

703890

-

-

?

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactose

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactose

Homo sapiens

-

i.e. H disaccharide

703919

-

-

?

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R

Homo sapiens

-

-

690409

-

-

?

UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R

UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R

Homo sapiens

A5X6H3, A5X6H4, A5X6H5, A5X6H7, A5X6H8, Q6L638

-

695221

-

-

?

UDP-galactose + blood group antigen H

UDP + alpha-D-galactosyl-blood group antigen H

Homo sapiens

-

-

703890

-

-

?

UDP-galactose + blood group antigen H

UDP + alpha-D-galactosyl-blood group antigen H

Homo sapiens

-

the alpha1,3-galactosyl epitope is a major xenotransplant antigen

706853

-

-

?

UDP-galactose + glycoprotein alpha-L-fucosyl-1,2-D-galactose

UDP + glycoprotein alpha-D-galactosyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose

Homo sapiens

-

acts on blood group substance

489131

-

-

?

UDP-galactose + glycoprotein alpha-L-fucosyl-1,2-D-galactose

UDP + glycoprotein alpha-D-galactosyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose

Papio sp.

-

acts on blood group substance

489131

-

-

?

additional information

?

-

Homo sapiens

-

histo-blood group B transferase transfers alpha-D-galatose to the antigen,H, while the B type enzyme transfers N-acetylgalactosamine, overview

706853

-

-

?

additional information

?

-

Homo sapiens

P16442

the enzyme shows weakened activity with B antigen variants resulting from ABO polymophisms, phenotyping and genotyping of ABO antigens, overview

706852

-

-

?