2.4.1.328: erythronolide mycarosyltransferase
This is an abbreviated version!
For detailed information about erythronolide mycarosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.328
-
2.4.1.328
-
saccharopolyspora
-
erythromycin
-
erythraea
-
macrolide
-
glycosyltransferases
-
eryciii
-
polyketide
-
erythromycin-producing
-
6-deoxyerythronolide
-
14-membered
-
d-desosamine
-
deoxysugars
-
macrolactone
-
antibioticus
-
aglycone
-
interspecies
-
methyltransferase
-
oleandomycin
- 2.4.1.328
-
saccharopolyspora
- erythromycin
- erythraea
-
macrolide
- glycosyltransferases
- eryciii
- polyketide
-
erythromycin-producing
-
6-deoxyerythronolide
-
14-membered
-
d-desosamine
-
deoxysugars
-
macrolactone
- antibioticus
-
aglycone
-
interspecies
- methyltransferase
- oleandomycin
Reaction
Synonyms
DesVII, dTDP-D-mycarose glycosyltransferase, EryBV, mycarosyl transferase
ECTree
Advanced search results
General Information
General Information on EC 2.4.1.328 - erythronolide mycarosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
-
deletion of eryBV gene results in the accumulation of 5-O-desosaminyl erythronolide B
physiological function
-
the enzyme is involved in the erythromycin biosynthetic pathway
physiological function
coexpression of glycosyltransferase DesVII and its auxiliary partner DesVIII in a Saccharopolyspora erythraea EryBV deletion mutant leads to an increased erythromycin A yield by 15% in comparison to Saccharopolyspora erythraea wild-type. DesVII/DesVIII replaced EryCIII to upload D-desosamine to C5 position of 3-O-mycarosyl erythronolide B and also in vivo attache L-mycarose, not D-desosamine to C3 position of erythronolide B with a higher activity than EryBV. Expression of DesVII in EryCIII and EryBV-CIII mutant strains partially restores the erythromycin A production, however, no erythromycin A is detected while DesVII is expressed in the EryBV mutant strain