2.4.1.313: protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

B3GALNT2, B3GalTN2, beta 1,3-N-acetylgalactosaminyltransferase2, beta-1,3-N-acetylgalactosaminyltransferase 2, beta1,3-N-acetylgalactosaminyltransferase II, beta1,3-N-acetylgalactosaminyltransferase-II, beta3GalNAc-T2, UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.313 protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

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Results	in table
6	AA Sequence
3	Application
1	Cloned(Commentary)
35	Disease/ Diagnostics
1	Expression
8	General Information
5	Localization
1	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
1	Posttranslational Modification
1	Reaction
9	Reference
13	Source Tissue
16	Substrates and Products (Substrate)
1	Subunits
15	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.4.1.313 - protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-alpha-D-galactosamine + 3-O-N-acetyl-beta-D-glucosaminyl-[Ser347 of human casein kinase II peptide]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl]-[Ser347 of human casein kinase II peptide]

Homo sapiens

Q8NCR0

-

759014

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[low-density lipoprotein receptor-related protein 1]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[low-density lipoprotein receptor-related protein 1]

Cricetulus griseus

A0A3L7H411

-

759500

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[nicastrin]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[nicastrin]

Cricetulus griseus

A0A3L7H411

-

759500

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

4 entries

UDP-N-acetyl-alpha-D-galactosamine + 4-nitrophenyl-beta-D-glucose

?

Homo sapiens

Q8NCR0

2% activity compared to GlcNAc-beta-benzyl

725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + calf fetuin

?

Homo sapiens

Q8NCR0

the enzyme efficiently transfers GalNAc to N-glycans of fetal calf fetuin, which is treated with neuraminidase and beta-galactosidase

725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + Gal-beta(1->3)(GlcNAcbeta(1->6))GalNAcalpha1-O-4-nitrophenyl

?

Homo sapiens

Q8NCR0

best acceptor substrate, 185% activity compared to GlcNAc-beta-benzyl

725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + Glc-NAcbeta(1->6)GalNAcalpha1-O-4-nitrophenyl

?

Homo sapiens

Q8NCR0

19% activity compared to GlcNAc-beta-benzyl

725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + GlcNAc-beta-benzyl

?

Homo sapiens

Q8NCR0

100% activity

725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + GlcNAcbeta(1->3)GalNAcalpha-4-nitrophenyl

UDP + GalNAcbeta(1->3)GlcNAcbeta(1->3)GalNAcalpha-4-nitrophenyl

Homo sapiens

Q8NCR0

8% activity compared to GlcNAc-beta-benzyl

725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + GlcNAcbeta(1->4)GlcNAcbeta1-O-benzyl

?

Homo sapiens

Q8NCR0

29% activity compared to GlcNAc-beta-benzyl

725358

-

-

?

additional information

?

-

2 entries

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

Danio rerio

-

-

723906

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

Homo sapiens

-

-

723906, 725164, 726488

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

Homo sapiens

Q8NCR0

-

726488, 725358

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]

Homo sapiens

-

-

725358

-

-

?

additional information

?

-

Homo sapiens

Q8NCR0

the enzyme shows no activity toward any glycolipid, Gal-beta-4-mitrophenyl, Gal-beta-O-4-nitrophenyl, Gal-NAc-alpha-benzyl, GalNAc-beta-4-nitrophenyl, Glc-alpha-4-nitrophenyl, GlcA-beta-4-nitrophenyl, Fuc-alpha-4-nitrophenyl, Xyl-alpha-4-nitrophenyl, Xyl-beta-4-nitrophenyl, Man-alpha-4-nitrophenyl, lactoside-benzyl, lactosylceramide, galactocenebroside type 1, paragloboside, globoside, Galbeta(1->4)GalNAc-alpha-4-nitrophenyl, Galbeta(1->3)GlcNAc-beta-4-nitrophenyl, and Galbeta(1->3)GalNAcalpha(core1)-4-nitrophenyl

725358

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme shows no activity toward any glycolipid, Gal-beta-4-mitrophenyl, Gal-beta-O-4-nitrophenyl, Gal-NAc-alpha-benzyl, GalNAc-beta-4-nitrophenyl, Glc-alpha-4-nitrophenyl, GlcA-beta-4-nitrophenyl, Fuc-alpha-4-nitrophenyl, Xyl-alpha-4-nitrophenyl, Xyl-beta-4-nitrophenyl, Man-alpha-4-nitrophenyl, lactoside-benzyl, lactosylceramide, galactocenebroside type 1, paragloboside, globoside, Galbeta(1->4)GalNAc-alpha-4-nitrophenyl, Galbeta(1->3)GlcNAc-beta-4-nitrophenyl, and Galbeta(1->3)GalNAcalpha(core1)-4-nitrophenyl

725358

-

-

?