2.4.1.312: protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about protein O-mannose beta-1,4-N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.312
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2.4.1.312
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muscular
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dystrophy
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muscle-eye-brain
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alpha-dystroglycan
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walker-warburg
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o-mannosylation
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malformation
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fukutin
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dystroglycanopathies
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dystroglycan
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laminin
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glycosyltransferase
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lissencephaly
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fukuyama
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hypoglycosylation
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alpha-dg
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cobblestone
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alpha-dystroglycanopathies
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largemyd
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beta1,2-n-acetylglucosaminyltransferase
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limb-girdle
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gmppb
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retrotransposal
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b3galnt2
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fukutin-related
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dystrophy-dystroglycanopathy
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ectopia
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o-mannosyltransferase
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laminin-binding
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polymicrogyria
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fukuyama-type
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medicine
- 2.4.1.312
- muscular
- dystrophy
- muscle-eye-brain
- alpha-dystroglycan
-
walker-warburg
-
o-mannosylation
-
malformation
-
fukutin
- dystroglycanopathies
-
dystroglycan
- laminin
- glycosyltransferase
- lissencephaly
-
fukuyama
-
hypoglycosylation
-
alpha-dg
-
cobblestone
- alpha-dystroglycanopathies
-
largemyd
-
beta1,2-n-acetylglucosaminyltransferase
-
limb-girdle
- gmppb
-
retrotransposal
- b3galnt2
-
fukutin-related
-
dystrophy-dystroglycanopathy
-
ectopia
-
o-mannosyltransferase
-
laminin-binding
-
polymicrogyria
-
fukuyama-type
- medicine
Reaction
Synonyms
GTDC2, O-mannose beta-1,4-N-acetylglucosaminyltransferase, POMGNT1, POMGNT2, protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 1, protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2, protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2, protein O-mannose beta1,4-N-acetylglucosaminyltransferase
ECTree
2.4.1.312 protein O-mannose beta-1,4-N-acetylglucosaminyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.312 - protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[IQEPPSRIVP-T-PTSPAIAPPT]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[IQEPPSRIVP-T-PTSPAIAPPT]
synthetic glycopeptide derived from alpha-dystroglycan
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?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[PKRVRRQIHA-T-PTPVTAIGPP]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[PKRVRRQIHA-T-PTPVTAIGPP]
synthetic glycopeptide derived from alpha-dystroglycan
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-
?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[TIRTRGAIIQ-T-LGPIQPTR]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[TIRTRGAIIQ-T-LGPIQPTR]
synthetic glycopeptide derived from alpha-dystroglycan
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-
?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[YVEP-T-AV]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[YVEP-T-AV]
synthetic glycopeptide derived from alpha-dystroglycan
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-
?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
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-
-
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?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
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-
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?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
synthetic acceptor, peptide corresponding to the mucin-like domain of human alpha-dystroglycan (residues 316-329), in which Thr-317 is modified by O-mannose but the remaining Thr/Ser residues are replaced with Ala
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?
additional information
?
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GTDC2 generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan in the endoplasmic reticulum
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?
additional information
?
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GTDC2 possesses a protein O-mannose beta-1,4-Nacetylglucosaminyltransferase activity. No substrate: UDP-GalNAc
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?
additional information
?
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GTDC2 possesses a protein O-mannose beta-1,4-Nacetylglucosaminyltransferase activity. No substrate: UDP-GalNAc
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?
additional information
?
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isoform POMGNT1 is promiscouos for O-mannosylated peptides
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additional information
?
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isoform POMGNT1 is promiscouos for O-mannosylated peptides
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additional information
?
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isoform POMGNT2 displays significant primary amino acid selectivity near the site of O-mannosylation. In the POMGNT2 acceptor motif, arginines at -6 and -8 and an Ile at -3 position are conserved in addition to the Pro at +1 and the Thr at +2
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additional information
?
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isoform POMGNT2 displays significant primary amino acid selectivity near the site of O-mannosylation. In the POMGNT2 acceptor motif, arginines at -6 and -8 and an Ile at -3 position are conserved in addition to the Pro at +1 and the Thr at +2
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