2.4.1.301: 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
This is an abbreviated version!
For detailed information about 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase, go to the full flat file.
Reaction
Synonyms
KanE, KanM2
ECTree
2.4.1.301 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.301 - 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + paromamine
UDP + ?
paromamine i.e. (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside. UDP-alpha-D-kanosamine is a better glycosyl donor than UDP-alpha-D-glucose
-
-
?
additional information
?
-
the enzyme can also accept UDP-alpha-D-glucose with lower efficiency
-
-
?
UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine
UDP + kanamycin A
the enzyme is involved in the biosynthetic pathway of kanamycins
-
-
?
UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine
UDP + kanamycin A
UDP-alpha-D-kanosamine i.e. uridine 5'-[3-(3-amino-3-deoxy-alpha-D-glucopyranosyl) diphosphate]
kanamycin A i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
-
?
UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine
UDP + kanamycin X
-
kanamycin X i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-(alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
-
?
UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine
UDP + kanamycin X
the enzyme is involved in the biosynthetic pathway of kanamycins
-
-
?
UDP-alpha-D-kanosamine + neamine
UDP + kanamycin B
the enzyme is involved in the biosynthetic pathway of kanamycins
-
-
?
UDP-alpha-D-kanosamine + neamine
UDP + kanamycin B
neamine i.e. (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
kanamycin B i.e. (1R,2S,3S,4R,6S)-4,6-diamino-3-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
-
?
UDP-alpha-D-kanosamine + paromamine
UDP + kanamycin C
the enzyme is involved in the biosynthetic pathway of kanamycins
-
-
?
UDP-alpha-D-kanosamine + paromamine
UDP + kanamycin C
paromamine i.e. (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
kanamycin C i.e. (1R,2S,3S,4R,6S)-4,6-diamino-3-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
-
?
