2.4.1.292: GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase

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For detailed information about GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase, go to the full flat file.

Reaction

3 UDP-N-acetyl-alpha-D-galactosamine +

Synonyms

PglH, pglH2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.292 GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase

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Results	in table
402	AA Sequence
5	Cloned(Commentary)
2	Crystallization (Commentary)
23	General Information
2	Inhibitors
2	Localization
1	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
49	Organism
1	Pathway
3	pH Optimum
32	Protein Variants
3	Purification (Commentary)
2	Reaction
12	Reference
13	Substrates and Products (Substrate)
3	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
11	Turnover Number [1/s]

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Cloned on EC 2.4.1.292 - GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

gene pglH, cj1129,par of the pgl gene cluster

Campylobacter jejuni

-

720384

gene pglH, expression of the N-terminally octahistidine-tagged enzyme containing a TEV cleavage sequence in Escherichia coli strain BL-21 RIL using a modified auto-induction method

Campylobacter jejuni

-

718851

gene pglH, overexpression of His-tagged PglH in Escherichia coli

Campylobacter jejuni

-

720888

gene pglH, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21-Gold (DE3)

Campylobacter jejuni

O86151

759837

gene pglH2, genotyping, overview. The variable presence of two open reading frames (ORFs) in the pgl locus includes a putative glycosyltransferase gene, pglG, in addition to a glucosyltransferase-expressing gene, pglH. One subcluster has pglH while the other has the pglH2 variant allele. Strains lacking these two ORFs retain the first 40 bp of pglG and the last 100 bp of pglH. Homologous recombination within the pgl loci through genomic analysis of 100 African serogroup A isolates is detected representing the clonal replacement of hypervirulent meningococcal clone sequence type 7 (ST-7) by the ST-2859 descendant clone. Polymorphisms exist at the gene level described for pglH and pglH2, where only one nonsynonymous mutation is accountable for the glycoform switch from Glc to GlcNAc. One subcluster has pglH while the other has the pglH2 variant allele. The pglH locus shows polymorphisms between STs along the whole gene. A 5' point mutation (guanosine to cytosine) adjacent to the polycytosine [poly(C)] tract is found in individuals 20, 22, and 33 carrying ST-192 isolates

Neisseria elongata subsp. glycolytica

-

759430