2.4.1.290: N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase
This is an abbreviated version!
For detailed information about N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase, go to the full flat file.
Reaction
Synonyms
Cj1125c, PglA
ECTree
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General Information
General Information on EC 2.4.1.290 - N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase
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metabolism
physiological function
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the enzyme is involved in a general N-linked glycosylation system that plays a role in pathogenicity
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a general N-linked glycosylation pathway, encoded by the pgl gene cluster, culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcalpha1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac, where Bac is bacillosamine, i.e. 2,4-diacetamido-2,4,6-trideoxyglucose, from a membrane-anchored undecaprenylpyrophosphate (Und-PP)-linked donor to the asparagine side chain of proteins at the Asn-X-Ser/Thr motif. For biosynthesis of Und-PP-linked heptasaccharide, PglA and PglJ add the first two GalNAc residues on to the isoprenoid-linked Bac carrier, respectively. Elongation of the trisaccharide with PglH results in a hexasaccharide revealing the polymerase activity of PglH. The final branching glucose is then added by PglI, which prefers native lipids for optimal activity. Pathway overview
metabolism
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PglF, PglE, PglD, PglC and PglA are the enzymes involved in the biosynthesis of an undecaprenyl diphosphate-linked disaccharide
metabolism
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the enzyme is involved in the biosynthesis of the sugar 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose, termed N,N'-diacetylbacillosamine or Bac2,4diNAc, the first carbohydrate in the glycoprotein N-linked heptasaccharide, in vitro biosynthesis of the complete heptasaccharide lipid-linked donor by coupling the action of eight enzymes, PglF, PglE, PglD, PglC, PglA, PglJ, PglH, and PglI, in the Pgl pathway
metabolism
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the enzyme is part of the enzyme system catalyzing the synthesis of the Und-PP-linked heptasaccharide GalNAc-alpha1,4- GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-Gal-NAc-alpha1,4-GalNAc-R1,3-Bac-R1,PP-Und, where Bac is the unusual sugar bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) that is only found in specific bacterial systems
metabolism
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the enzyme is involved in the biosynthesis of the sugar 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose, termed N,N'-diacetylbacillosamine or Bac2,4diNAc, the first carbohydrate in the glycoprotein N-linked heptasaccharide, in vitro biosynthesis of the complete heptasaccharide lipid-linked donor by coupling the action of eight enzymes, PglF, PglE, PglD, PglC, PglA, PglJ, PglH, and PglI, in the Pgl pathway
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metabolism
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a general N-linked glycosylation pathway, encoded by the pgl gene cluster, culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcalpha1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac, where Bac is bacillosamine, i.e. 2,4-diacetamido-2,4,6-trideoxyglucose, from a membrane-anchored undecaprenylpyrophosphate (Und-PP)-linked donor to the asparagine side chain of proteins at the Asn-X-Ser/Thr motif. For biosynthesis of Und-PP-linked heptasaccharide, PglA and PglJ add the first two GalNAc residues on to the isoprenoid-linked Bac carrier, respectively. Elongation of the trisaccharide with PglH results in a hexasaccharide revealing the polymerase activity of PglH. The final branching glucose is then added by PglI, which prefers native lipids for optimal activity. Pathway overview
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