2.4.1.288: galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase
This is an abbreviated version!
For detailed information about galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.288
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2.4.1.288
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galactan
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mycobacterial
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tuberculosis
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galf
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polysaccharide
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udp-galf
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udp-galactofuranose
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glycosyltransferases
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arabinogalactan
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glycoconjugate
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mycolic
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trisaccharide
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tetrasaccharide
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mycolyl-arabinogalactan-peptidoglycan
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galactosyltransferase
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polymerizing
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l-arabinofuranose
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galactomannans
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anti-tuberculosis
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fungal-type
- 2.4.1.288
- galactan
-
mycobacterial
- tuberculosis
-
galf
- polysaccharide
-
udp-galf
- udp-galactofuranose
- glycosyltransferases
- arabinogalactan
- glycoconjugate
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mycolic
- trisaccharide
- tetrasaccharide
-
mycolyl-arabinogalactan-peptidoglycan
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galactosyltransferase
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polymerizing
- l-arabinofuranose
- galactomannans
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anti-tuberculosis
-
fungal-type
Reaction
28 UDP-alpha-D-galactofuranose + = 28 UDP +
Synonyms
galactofuranosyl transferase 2, galactofuranosyltransferase, galactosyl transferase, GalTr, GlfT, GlfT2, LmjF.25.0010, LMJF_25_0010, LPG1, LPG1G, LPG1G2, LPG1L, Rv3808c
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General Information
General Information on EC 2.4.1.288 - galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase
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metabolism
physiological function
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GlfT2 catalyzes the formation of mycobacterial galactan, mediating galactan polymerization using only one active site that manifests dual regioselectivity
metabolism
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the enzyme catalyzes the addition of the third and subsequent Galf residues, but not the first two, to the lipid template in galactan synthesis
metabolism
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the enzyme catalyzes the formation of both beta-5-linked and beta-6-linked galactofuranoses and is responsible for the synthesis of the bulk galactan portion of AG
metabolism
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the enzyme catalyzes the formation of both beta-5-linked and beta-6-linked galactofuranoses and is responsible for the synthesis of the bulk galactan portion of AG
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metabolism
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GlfT2 catalyzes the formation of mycobacterial galactan, mediating galactan polymerization using only one active site that manifests dual regioselectivity
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GlfT2 is essential for mycobacterial cell wall biosynthesis
physiological function
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the enzyme mediates the cell wall galactan production through a sequence-specific polymerization
physiological function
the free-energy barriers for beta-(1-6) and beta-(1-5) linkages are mainly the same, 29.6 kcal/mol for the beta-(1-6) reaction and 28.2 kcal/mol for the beta-(1-5) reaction. Both reactions occur at a single catalytic site with a SN2-type reaction mechanism with a dissociative oxocarbenium ion-like transition state for both the beta-(1-6) and beta-(1-5) reactions. In both reactions the furanose ring adopts an utterly flat ring in the transition state
physiological function
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the free-energy barriers for beta-(1-6) and beta-(1-5) linkages are mainly the same, 29.6 kcal/mol for the beta-(1-6) reaction and 28.2 kcal/mol for the beta-(1-5) reaction. Both reactions occur at a single catalytic site with a SN2-type reaction mechanism with a dissociative oxocarbenium ion-like transition state for both the beta-(1-6) and beta-(1-5) reactions. In both reactions the furanose ring adopts an utterly flat ring in the transition state
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