2.4.1.278: 3-alpha-mycarosylerythronolide B desosaminyl transferase
This is an abbreviated version!
For detailed information about 3-alpha-mycarosylerythronolide B desosaminyl transferase, go to the full flat file.
Word Map on EC 2.4.1.278
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2.4.1.278
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erythromycin
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saccharopolyspora
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macrolide
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erythraea
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polyketide
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glycosyltransferases
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deoxysugars
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d-desosamine
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erythromycin-producing
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macrolactone
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peucetius
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6-deoxyerythronolide
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medicine
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spinosyns
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interspecies
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14-membered
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antibioticus
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auxiliary
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aglycone
- 2.4.1.278
- erythromycin
-
saccharopolyspora
-
macrolide
- erythraea
- polyketide
- glycosyltransferases
-
deoxysugars
-
d-desosamine
-
erythromycin-producing
-
macrolactone
- peucetius
-
6-deoxyerythronolide
- medicine
-
spinosyns
-
interspecies
-
14-membered
- antibioticus
-
auxiliary
-
aglycone
Reaction
Synonyms
DesVII, EryCIII, glycosyltransferase EryCIII
ECTree
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General Information
General Information on EC 2.4.1.278 - 3-alpha-mycarosylerythronolide B desosaminyl transferase
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physiological function
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the enzyme is involved in erythromycin biosynthesis
physiological function
coexpression of glycosyltransferase DesVII and its auxiliary partner DesVIII in a Saccharopolyspora erythraea EryBV deletion mutant leads to an increased erythromycin A yield by 15% in comparison to Saccharopolyspora erythraea wild-type. DesVII/DesVIII replaced EryCIII to upload D-desosamine to C5 position of 3-O-mycarosyl erythronolide B and also in vivo attache L-mycarose, not D-desosamine to C3 position of erythronolide B with a higher activity than EryBV. Expression of DesVII in EryCIII and EryBV-CIII mutant strains partially restores the erythromycin A production, however, no erythromycin A is detected while DesVII is expressed in the EryBV mutant strain