2.4.1.270: mannosylglucosyl-3-phosphoglycerate synthase

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For detailed information about mannosylglucosyl-3-phosphoglycerate synthase, go to the full flat file.

Reaction

Synonyms

MggA, RB5546

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.270 mannosylglucosyl-3-phosphoglycerate synthase

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Results	in table
7	AA Sequence
2	Cloned(Commentary)
2	Inhibitors
4	KM Value [mM]
7	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
3	Organism
1	Pathway
2	pH Optimum
1	pH Range
1	pI Value
1	Purification (Commentary)
1	Reaction
3	Reference
3	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
3	Subunits
5	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.270 - mannosylglucosyl-3-phosphoglycerate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

Petrotoga mobilis

A9BHJ0

the enzyme is involved in the phosphorylating pathway for synthesis of the solute mannosylglucosylglycerate. In Petrotoga mobilis two alternative pathways for the synthesis of the rare solute mannosylglucosylglycerate are proposed. The first one is a a phosphorylating pathway (with a phosphorylated intermediate) from 3-phosphoglycerate and UDP-glucose to the final solute. The second nonphosphorylating pathway (no phosphorylated intermediates) could represent an alternative route for the synthesis of mannosylglucosylglycerate in Petrotoga mobilis that could lead to the direct conversion of glucosylglycerate and GDP-mannose to mannosylglucosylglycerate. Pathway multiplicity likely reflects a crucial role for mannosylglucosylglycerate in the physiology of Petrotoga mobilis mobilis during stress adaptation

708933

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