2.4.1.27: DNA beta-glucosyltransferase

This is an abbreviated version!
For detailed information about DNA beta-glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.27

2.4.1.27

glycosyltransferases

bacteriophage

glucosylate

interdomain

base-flipping

duplex

tdp

maltodextrin

substrate-free

co-crystal

dna-modifying

udp-glcnac

5-hydroxymethyl

vancomycin

glycosylases

ligand-bound

abasic

sialyltransferases

flipped-out

bidomain

udp-n-acetylglucosamine

analysis

medicine

Reaction

beta-D-glucosyl-5-hydroxymethylcytosine containing DNA

Synonyms

beta-GT, BGT, glucosyltransferase, uridine diphosphoglucose-deoxyribonucleate beta-, GT-B glycosyltransferase, More, T4 beta-glucosyl transferase, T4 beta-glucosyltransferase, T4 phage beta-glucosyltransferase, T4-beta-glucosyl transferase, T4-HMC-beta-glucosyl transferase, UDP glucose-DNA beta-glucosyltransferase, uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.27 DNA beta-glucosyltransferase

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Results	in table
2	AA Sequence
2	Application
1	CAS Registry Number
1	Cloned(Commentary)
8	Crystallization (Commentary)
3	IC50 Value
5	Inhibitors
5	kcat/KM [mM/s]
4	Ki Value [mM]
6	KM Value [mM]
3	Metals/Ions
8	Natural Substrates/ Products (Substrates)
12	Organism
24	PDB ID
4	Reaction
1	Reaction Type
12	Reference
1	Source Tissue
23	Substrates and Products (Substrate)
1	Subunits
14	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Reference

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Reference on EC 2.4.1.27 - DNA beta-glucosyltransferase

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489027

Freemont, P.S.; Ruger, W.

Crystallization and preliminary X-ray studies of T4 phage beta-glucosyltransferase

J. Mol. Biol.

203

525-526

1988

Tequatrovirus T4

2974086

489028

Lariviere, L.; Kurzeck, J.; Aschke-Sonnenborn, U.; Rueger, W.; Morera, S.

Crystallization and preliminary crystallographic study of a ternary complex between the T4 phage beta-glucosyltransferase, uridine diphosphoglucose and a DNA fragment containing an abasic site

Acta Crystallogr. Sect. D

1484-1486

2002

Tequatrovirus T4 (P04547)

12198310

489029

Morera, S.; Lariviere, L.; Kurzeck, J.; Aschke-Sonnenborn, U.; Freemont, P.S.; Janin, J.; Ruger, W.

High resolution crystal structures of T4 phage beta-glucosyltransferase: Induced fit and effect of substrate and metal binding

J. Mol. Biol.

311

569-577

2001

Tequatrovirus T4

11493010

489030

Vrielink, A.; Rueger, W.; Driessen, H.P.C.; Freemont, P.S.

Crystal structure of the DNA modifying enzyme beta-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose

EMBO J.

3413-3422

1994

Tequatrovirus T4

8062817

489031

Morera, S.; Imberty, A.; Aschke-Sonnenborn, U.; Ruger, W.; Freemont, P.S.

T4 phage beta-glucosyltransferase: Substrate binding and proposed catalytic mechanism

J. Mol. Biol.

292

717-730

1999

Tequatrovirus T4

10497034

489032

Lariviere, L.; Morera, S.

A base-flipping mechanism for the T4 phage beta-glucosyltransferase and identification of a transition-state analog

J. Mol. Biol.

324

483-490

2002

Tequatrovirus T4 (P04547)

12445783

489033

Artymiuk, P.J.; Rice, D.W.; Poirrette, A.R.; Willett, P.

beta-Glucosyltransferase and phosphorylase reveal their common theme

Nat. Struct. Biol.

117-120

1995

Tequatrovirus T4

7749914

489034

Lariviere, L.; Gueguen-Chaignon, V.; Morera, S.:

Crystal structures of the T4 phage beta-glucosyltransferase and the D100A mutant in complex with UDP-glucose: Glucose binding and identification of the catalytic base for a direct displacement mechanism

J. Mol. Biol.

330

1077-1086

2003

Tequatrovirus T4 (P04547)

12860129

659730

Lariviere, L.; Sommer, N.; Morera, S.

Structural evidence of a passive base-flipping mechanism for AGT, an unusual GT-B glycosyltransferase

J. Mol. Biol.

352

139-150

2005

Tequatrovirus T4

16081100

718919

Terragni, J.; Bitinaite, J.; Zheng, Y.; Pradhan, S.

Biochemical characterization of recombinant alpha-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes

Biochemistry

1009-1019

2012

Tequatrovirus T4

22229759

758468

Yin, H.; Yang, Z.; Wang, H.; Zhou, Y.; Ai, S.

Electrochemical biosensor for hydroxymethylated DNA detection and beta-glucosyltransferase activity assay based on enzymatic catalysis triggering signal amplification

Sens. Actuators B Chem.

243

602-608

2017

Tequatrovirus T4

758470

Jiang, W.; Yin, H.; Zhou, Y.; Duan, J.; Li, H.; Wang, M.; Waterhouse, G.; Ai, S.

A novel electrochemiluminescence biosensor for the detection of 5-methylcytosine, TET 1 protein and beta-glucosyltransferase activities based on gold nanoclusters-H2O2 system

Sens. Actuators B Chem.

274

144-151

2018

Tequatrovirus T4