2.4.1.268: glucosylglycerate synthase
This is an abbreviated version!
For detailed information about glucosylglycerate synthase, go to the full flat file.
Reaction
Synonyms
Ggs
ECTree
2.4.1.268 glucosylglycerate synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.4.1.268 - glucosylglycerate synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP-glucose + glycerate
2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
-
in Persephonella marina two pathways for synthesis of glucosylglycerate are present: 1. the single-step pathway in with glucosylglycerate synthase (Ggs) catalyzes the synthesis of 2-(alpha-D-glucosyl)-D-glycerate in one-step from ADP-glucose and D-glycerate, and 2. the two-step pathway in which glucosyl-3-phosphoglycerate synthase (GpgS) catalyzes the conversion of NDP-glucose and D-3-phosphoglycerate into glucosyl-3-phosphoglycerate, which is then converted to 2-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase (GpgP)
-
-
?
GDP-alpha-D-glucose + D-glycerate
2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP
-
-
-
-
?
UDP-glucose + D-glycerate
2-O-(alpha-D-glucopyranosyl)-D-glycerate + UDP
-
-
-
-
?
additional information
?
-
-
activity is not observed with: ADP-glucose, UDP-galactose, GDP-fucose, GDP-mannose or ADP-ribose. D-Glycerate is the only glucosylacceptor. No activity with mannose-6-phosphate, glucose-1-phosphate, glucose-6-phosphate, trehalose-6-phosphate, and fructose-6-phosphate or with the three-carbon compounds D-3-phosphoglycerate, D-2-phosphoglycerate, D-glycerate, L-glycerate, glycerol, and glycerol-3-phosphate
-
-
?
ADP-glucose + D-glycerate
2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
-
ADP-glucose is the preferred substrate (0.2843 mol/min*mg), it can be partially replaced by UDP-glucose or GDP-glucose in decreasing order of efficiency (0.047 and 0.0274 mol/min*mg, respectively)
-
-
?
ADP-glucose + D-glycerate
2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
the enzyme is involved in the nonphosphorylating pathway for synthesis of the solute mannosylglucosylglycerate. In Petrotoga mobilis two alternative pathways for the synthesis of the solute mannosylglucosylglycerate are proposed. The first one is a phosphorylating pathway (with a phosphorylated intermediate) from 3-phosphoglycerate and UDP-glucose to the final solute. The second nonphosphorylating pathway (no phosphorylated intermediates) could represent an alternative route for the synthesis of mannosylglucosylglycerate in Petrotoga mobilis that could lead to the direct conversion of glucosylglycerate and GDP-mannose to mannosylglucosylglycerate. Pathway multiplicity likely reflects a crucial role for mannosylglucosylglycerate in the physiology of Petrotoga mobilis during stress adaptation
-
-
?
ADP-glucose + D-glycerate
2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
formation of 2-O-(alpha-D-glucosyl)-D-glycerate is strongly favored. ADP-glucose is the preferred substrate for the recombinant glucosylglycerate synthase, which can be partially replaced by UDP-glucose with a very low efficiency. D-Glycerate is the only acceptor
-
-
?
