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2.4.1.267: dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase

This is an abbreviated version!
For detailed information about dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.267

Reaction

dolichyl beta-D-glucosyl phosphate
+
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
=
alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
 +
dolichyl phosphate

Synonyms

ALG6, hALG6

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.267 dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase

Reference

topprint

Reference on EC 2.4.1.267 - dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Drijvers, J.M.; Lefeber, D.J.; de Munnik, S.A.; Pfundt, R.; van de Leeuw, N.; Marcelis, C.; Thiel, C.; Koerner, C.; Wevers, R.A.; Morava, E.
Skeletal dysplasia with brachytelephalangy in a patient with a congenital disorder of glycosylation due to ALG6 gene mutations
Clin. Genet.
77
507-509
2010
Homo sapiens (Q9Y672)
Manually annotated by BRENDA team
Reiss, G.; te Heesen, S.; Zimmerman, J.; Robbins, P.W.; Aebi, M.
Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway
Glycobiology
6
493-498
1996
Saccharomyces cerevisiae (Q12001)
Manually annotated by BRENDA team
Westphal, V.; Kjaergaard, S.; Schollen, E.; Martens, K.; Grunewald, S.; Schwartz, M.; Matthijs, G.; Freeze, H.H.
A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency
Hum. Mol. Genet.
11
599-604
2002
Homo sapiens (Q9Y672)
Manually annotated by BRENDA team
Westphal, V.; Xiao, M.; Kwok, P.Y.; Freeze, H.H.
Identification of a frequent variant in ALG6, the cause of congenital disorder of glycosylation-Ic
Hum. Mutat.
22
420-421
2003
Homo sapiens (Q9Y672)
Manually annotated by BRENDA team
Runge, K.W.; Huffaker, T.C.; Robbins, P.W.
Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway
J. Biol. Chem.
259
412-417
1983
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Westphal, V.; Schottstädt, C.; Marquardt, T.; Freeze, H.H.
Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic
Mol. Genet. Metab.
70
219-223
2000
Homo sapiens (Q9Y672)
Manually annotated by BRENDA team
De Pourcq, K.; Tiels, P.; Van Hecke, A.; Geysens, S.; Vervecken, W.; Callewaert, N.
Engineering Yarrowia lipolytica to produce glycoproteins homogeneously modified with the universal Man3GlcNAc2 N-glycan core
PLoS ONE
7
e39976
2012
Yarrowia lipolytica
Manually annotated by BRENDA team
Shrimal, S.; Gilmore, R.
Reduced expression of the oligosaccharyltransferase exacerbates protein hypoglycosylation in cells lacking the fully assembled oligosaccharide donor
Glycobiology
25
774-783
2015
Cricetulus griseus (G3GZD6), Homo sapiens (Q9Y672)
Manually annotated by BRENDA team
Zhou, B.; Zhao, Y.; Liu, H.; Luo, S.; Amos, C.; Lee, J.; Li, X.; Nan, H.; Wei, Q.
Novel genetic variants of ALG6 and GALNTL4 of the glycosylation pathway predict cutaneous melanoma-specific survival
Cancers (Basel)
12
288
2020
Homo sapiens (Q9Y672)
Manually annotated by BRENDA team
Bloch, J.S.; Pesciullesi, G.; Boilevin, J.; Nosol, K.; Irobalieva, R.N.; Darbre, T.; Aebi, M.; Kossiakoff, A.A.; Reymond, J.L.; Locher, K.P.
Structure and mechanism of the ER-based glucosyltransferase ALG6
Nature
579
443-447
2020
Saccharomyces cerevisiae (Q12001)
Manually annotated by BRENDA team