2.4.1.260: dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
This is an abbreviated version!
For detailed information about dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.260
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2.4.1.260
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n-glycans
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lipid-linked
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asparagine-linked
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hypoglycosylation
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glc3man9glcnac2
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medicine
- 2.4.1.260
- n-glycans
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lipid-linked
-
asparagine-linked
-
hypoglycosylation
- glc3man9glcnac2
- medicine
Reaction
Synonyms
ALG12, ALG12 alpha1,6mannosyltransferase, ALG12 mannosyltransferase, alpha1-6-mannosyltransferase, Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase, dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase, dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase, EBS4, EC 2.4.1.130, TbALG12
ECTree
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Systematic Name
Systematic Name on EC 2.4.1.260 - dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
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dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate.