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2.4.1.260: dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

This is an abbreviated version!
For detailed information about dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.260

Reaction

dolichyl beta-D-mannosyl phosphate
+
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
=
alpha-D-Man-alpha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
+
dolichyl phosphate

Synonyms

ALG12, ALG12 alpha1,6mannosyltransferase, ALG12 mannosyltransferase, alpha1-6-mannosyltransferase, Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase, dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase, dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase, EBS4, EC 2.4.1.130, TbALG12

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.260 dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

Reference

Reference on EC 2.4.1.260 - dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chantret, I.; Dupre, T.; Delenda, C.; Bucher, S.; Dancourt, J.; Barnier, A.; Charollais, A.; Heron, D.; Bader-Meunier, B.; Danos, O.; Seta, N.; Durand, G.; Oriol, R.; Codogno, P.; Moore, S.E.H.
Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase
J. Biol. Chem.
277
25815-25822
2002
Homo sapiens (Q9BV10), Homo sapiens
Manually annotated by BRENDA team
Grubenmann, C.E.; Frank, C.G.; Kjaergaard, S.; Berger, E.G.; Aebi, M.; Hennet, T.
ALG12 mannosyltransferase defect in congenital disorder of glycosylation type Ig
Hum. Mol. Genet.
11
2331-2339
2002
Homo sapiens (Q9BV10), Homo sapiens
Manually annotated by BRENDA team
Cipollo, J.F.; Trimble, R.B.
The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man-residues of Glc(3)Man(9)GlcNAc(2)-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus
Glycobiology
12
749-762
2002
Saccharomyces cerevisiae (P53730), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hong, Z.; Jin, H.; Fitchette, A.C.; Xia, Y.; Monk, A.M.; Faye, L.; Li, J.
Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis
Plant Cell
21
3792-3802
2009
Arabidopsis thaliana (A8MR93), Arabidopsis thaliana
Manually annotated by BRENDA team
Izquierdo, L.; Mehlert, A.; Ferguson, M.A.
The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases
Glycobiology
22
696-703
2012
Trypanosoma brucei
Manually annotated by BRENDA team
Hong, Z.; Kajiura, H.; Su, W.; Jin, H.; Kimura, A.; Fujiyama, K.; Li, J.
Evolutionarily conserved glycan signal to degrade aberrant brassinosteroid receptors in Arabidopsis
Proc. Natl. Acad. Sci. USA
109
11437-11442
2012
Arabidopsis thaliana (A8MR93)
Manually annotated by BRENDA team
Massarweh, A.; Bosco, M.E.; Iatmanen-Harbi, S.; Tessier, C.; Amana, L.; Busca, P.; Chantret, I.; Gravier-Pelletier, C.; Moore, S.E.
Brefeldin A promotes the appearance of oligosaccharyl phosphates (OSP) derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells
J. Lipid Res.
57
1477-1491
2016
Homo sapiens
Manually annotated by BRENDA team
Trempel, F.; Eschen-Lippold, L.; Bauer, N.; Ranf, S.; Westphal, L.; Scheel, D.; Lee, J.
A mutation in asparagine-linked glycosylation 12 (ALG12) leads to receptor misglycosylation and attenuated responses to multiple microbial elicitors
FEBS Lett.
2020
1873-3468
2020
Arabidopsis thaliana (A8MR93)
Manually annotated by BRENDA team
Sturiale, L.; Bianca, S.; Garozzo, D.; Terracciano, A.; Agolini, E.; Messina, A.; Palmigiano, A.; Esposito, F.; Barone, C.; Novelli, A.; Fiumara, A.; Jaeken, J.; Barone, R.
ALG12-CDG novel glycophenotype insights endorse the molecular defect
Glycoconj. J.
36
461-472
2019
Homo sapiens (Q9BV10), Homo sapiens
Manually annotated by BRENDA team