2.4.1.26: DNA alpha-glucosyltransferase

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For detailed information about DNA alpha-glucosyltransferase, go to the full flat file.

Reaction

Synonyms

AGT, glucosyltransferase, uridine diphosphoglucose-deoxyribonucleate alpha-, T2-HMC-alpha-glucosyl transferase, T4-HMC-alpha-glucosyl transferase, T6-HMC-alpha-glucosyl transferase, UDPglucose-DNA alpha-glucosyltransferase, uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.26 DNA alpha-glucosyltransferase

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Results	in table
2	Activating Compound
2	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Metals/Ions
1	Molecular Weight [Da]
6	Organism
9	PDB ID
1	pH Optimum
6	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
6	Reference
4	Specific Activity [micromol/min/mg]
7	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.4.1.26 - DNA alpha-glucosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-glucose + hydroxymethylated DNA

UDP + glycosylated hydroxymethylated DNA

Tequatrovirus T4

-

Glu22 seems not to be responsible for activation of the nucleophilic attack, Ser106 and Glu311 probably form a salt bridge in the closed enzyme formation, Glu311 is probably involved in interaction with UDP-glucose, Arg236, Arg256 and Met231 are probably involved in interaction with the DNA

657775

-

-

?

UDPglucose + 5-hydroxymethylcytosine containing DNA

UDP + alpha-glucosyl-5-hydroxymethylcytosine containing DNA

4 entries

additional information

?

-

Tequatrovirus T4

-

hydroxymethylated DNA binding activities of wild-type and mutant enzymes, the enzyme undergoes a conformational change from a substrate-free open form to a closed substrate-binding form stabilized by several salt bridges and probably involving Ser106 and Glu22

657775

-

-

?

UDPglucose + 5-hydroxymethylcytosine containing DNA

UDP + alpha-glucosyl-5-hydroxymethylcytosine containing DNA

Enterobacteria phage T6

-

extent of glucosylation varies between 50% and 80% of the amount of hydroxymethylcytosine residues calculated to be present, T4 DNA with no unsubstituted hydroxymethylcytosine groups does not serve as acceptor, T2 DNA: no activity with enzyme from T2-infected cells, small activity with enzyme from T4- and T6-infected cells

489024

-

489024

?

UDPglucose + 5-hydroxymethylcytosine containing DNA

UDP + alpha-glucosyl-5-hydroxymethylcytosine containing DNA

Escherichia phage T2

-

-

489024

-

489024

?

UDPglucose + 5-hydroxymethylcytosine containing DNA

UDP + alpha-glucosyl-5-hydroxymethylcytosine containing DNA

Tequatrovirus T4

-

-

489025, 489026

-

-

?

UDPglucose + 5-hydroxymethylcytosine containing DNA

UDP + alpha-glucosyl-5-hydroxymethylcytosine containing DNA

Tequatrovirus T4

-

extent of glucosylation varies between 50% and 80% of the amount of hydroxymethylcytosine residues calculated to be present, T4 DNA with no unsubstituted hydroxymethylcytosine groups does not serve as acceptor, T2 DNA: no activity with enzyme from T2-infected cells, small activity with enzyme from T4- and T6-infected cells

489024

-

489024

?