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2.4.1.255: protein O-GlcNAc transferase

This is an abbreviated version!
For detailed information about protein O-GlcNAc transferase, go to the full flat file.

Word Map on EC 2.4.1.255

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
[protein]-L-serine
=
UDP
 +
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine

Synonyms

beta-N-acetylglucosaminidase, EGF domain-specific O-GlcNAc transferase, EGF domain-specific O-linked N-acetylglucosamine transferase, EOGT, EOGT1, epidermal growth factor domain-specific O-GlcNAc transferase, glycosyltransferase OGT, Gtf1, GtfA, hOGT, HsOGT, human OGT, mammalian OGT, mOGT, More, N-acetylglucosamine transferase, N-acetylglucosamine-peptide N-acetylglucosaminyltransferase, N-acetylglucosaminyltransferase, ncOGT, nuclear cytoplasmic OGT, nucleocytoplasmic glycosyltransferase, nucleocytoplasmic OGT, O-GlcNAc protein, O-GlcNAc transferase, O-GlcNAc transferase OGT, O-GlcNAc-transferase, O-GlcNAcase, O-glycosylated protein p135, O-linked beta-N-acetylglucosamine transferase, O-linked beta-N-acetylglucosaminyltransferase, O-linked GlcNAc transferase, O-linked N-acetylglucosamine transferase, O-linked N-acetylglucosaminyltransferase, O-N-acetylglucosamine (O-GlcNAc) transferase, OGT, OGT p110, OGT protein, ogta, OGTase, OGTase protein, ogtb, p135, Protein SECRET AGENT, SEC, SECRET AGENT, sOGT, spindly, SPY, super sex combs, Sxc, Synpcc7942_0051, transferase OGT, UDP-GlcNAc: polypeptide O-N-acetylglucosaminyltransferase, UDP-GlcNAc:polypeptidyl transferase, UDP-N-acetylglucosaminyl transferase, uridine diphosphate-N-acetyl-D-glucosamine:polypeptidyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase, XcOGT, XcOGT protein

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.255 protein O-GlcNAc transferase

Activating Compound

Activating Compound on EC 2.4.1.255 - protein O-GlcNAc transferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ataxin-10
-
CoCl2
-
stress treatment induces higher levels of OGT protein expression
D-glucose
immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose
dithiothreitol
-
increases the activity of wild type OGT
ethanol
-
stress treatment induces higher levels of OGT protein expression
H2O2
-
stress treatment induces higher levels of OGT protein expression
hyperglycemia
-
increases O-GlcNAc levels in pancreatic beta cells, which appears to interfere with beta-cell function
-
Insulin
-
tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment
-
NaCl
-
stress treatment induces higher levels of OGT protein expression
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
-
inhibitor of O-GlcNAcase, increase of the level of O-GlcNAc modifications
sodium arsenite
-
stress treatment induces higher levels of OGT protein expression
UDP-N-acetyl-D-glucosamine
-
-
UVB light
-
stress treatment induces higher levels of OGT protein expression
-
vanadate
-
tyrosine phosphatase inhibitor sodium vanadate, treatment increases OGT activity. When insulin is added to cells preincubated with sodium vanadate, there is a further increase in OGT activity versus inhibitor alone
additional information
-