2.4.1.245: alpha,alpha-trehalose synthase
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For detailed information about alpha,alpha-trehalose synthase, go to the full flat file.
Reaction
Synonyms
PH1035, TaTS, TmTreT, trehalose glycosyltransferring synthase, Trehalose synthase, TreT
ECTree
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Reaction
Reaction on EC 2.4.1.245 - alpha,alpha-trehalose synthase
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NDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + NDP
reaction mechanism, overview. The acceptor binding site of TreT shows a wide and commodious groove and lacks the long flexible loop that plays a gating role in ligand binding in trehalose phosphate synthase, TPS, EC 2.4.1.15. A wide space at the fissure between two domains and the relative shift of the N-domain in one of the crystal forms suggest that an interactive conformational change between two domains would occur, allowing a more compact architecture for catalysis