2.4.1.244: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

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For detailed information about N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

B4GALNT3, beta 1,4-N-acetylgalactosaminyltransferase-A, beta1,4-N-acetylgalactosaminyltransferase, beta1,4-N-acetylgalactosaminyltransferase II, beta1,4-N-acetylgalactosaminyltransferase III, beta1,4-N-acetylgalactosaminyltransferase IV, beta1,4-N-acetylgalactosaminyltransferase-III, beta4GalNAc-T3, beta4GalNAc-T4, beta4GalNAcT, beta4GalNAcT-II, beta4GalNAcTA, beta4GalNAcTB, N,N'-diacetyllactosediamine synthase, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.244 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

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1	Activating Compound
1624	AA Sequence
1	Application
2	CAS Registry Number
9	Cloned(Commentary)
39	Disease/ Diagnostics
1	Expression
2	General Information
1	Inhibitors
3	Localization
5	Natural Substrates/ Products (Substrates)
13	Organism
2	Pathway
1	Protein Variants
3	Purification (Commentary)
1	Reaction
12	Reference
23	Source Tissue
37	Substrates and Products (Substrate)
24	Synonyms
1	Systematic Name

General Information

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General Information on EC 2.4.1.244 - N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Homo sapiens

Q6L9W6

B4GALNT3 overexpression enhances colon cancer cell malignant phenotypes in vitro and in vivo. B4GALNT3 knockdown suppresses EGF-induced phosphorylation of epithelial growth factor receptor, EGFR, and its downstream signaling molecules. B4GALNT3 knockdown inhibits EGFR activity, decreases EGF-induced migration and invasion in colon cancer cells, and promotes EGFR degradation in colon cancer cells, overview

736917

physiological function

Homo sapiens

Q6L9W6

beta1,4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells, B4GALNT3 regulates cancer stemness and the invasive properties of colon cancer cells through modifying EGFR glycosylation and signaling. B4GALNT3 expression is positively correlated with advanced stages and poor survival in colorectal cancer patients

736917