2.4.1.232: initiation-specific alpha-1,6-mannosyltransferase
This is an abbreviated version!
For detailed information about initiation-specific alpha-1,6-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.232
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2.4.1.232
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mannans
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mannoproteins
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alpha-1,6-linked
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alpha-1,2-mannosidase
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man8glcnac2
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pyridylaminated
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mannoses
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cis-golgi
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man5glcnac2-pp-dol
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polymannose
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drug development
- 2.4.1.232
- mannans
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mannoproteins
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alpha-1,6-linked
- alpha-1,2-mannosidase
- man8glcnac2
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pyridylaminated
- mannoses
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cis-golgi
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man5glcnac2-pp-dol
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polymannose
- drug development
Reaction
Synonyms
AFUA_2G01450, alpha-1,6-mannosyltransferase, alpha-1,6-MT, alpha-mannosyltransferase, alpha1,6-mannosyltransferase KlOch1p, alpha1-6-mannosyltransferase, Anl1p, Anp1p, Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase, GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase, GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase, glycolipid 6-alpha-mannosyltransferase, glycoprotein alpha1-6-mannosyltransferase, HpOCH1, initiation-specific alpha-1,6-mannosyltransferase, mannosyltransferase, guanosine diphosphomannose-glycoprotein alpha1-6-, Mnn9, Mnn9p, och1+, Och1p, ScMnn9p, SpOch1p, TbALG12, VdOCH1, YlOch1p
ECTree
2.4.1.232 initiation-specific alpha-1,6-mannosyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.4.1.232 - initiation-specific alpha-1,6-mannosyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-mannose + oligosaccharide acceptor
?
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Mnn9p is involved in protein mannosylation, incorporates alpha-1,6-linked mannose residues, the elongation of the N-glycan outer chain, initiated by Och1p, is continued by two mannosyltransferase complexes: V-complex composed of Mnn9p and Van1p and A-complex composed of Mnn9p, Anp1p, Hoc1p, Mnn10p and Mnn11p
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?
additional information
?
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transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1-6)-D-mannosyl-D-mannose linkage
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?
additional information
?
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transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1-6)-D-mannosyl-D-mannose linkage
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?
additional information
?
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the enzyme is required for cell-wall organization and proper functioning of the secretory pathway
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?
additional information
?
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HpOCH1 is the key enzyme responsible for initiating N-linked outer chain biosynthesis by adding the first alpha-1,6-mannose residue onto the core oligosaccharide
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?
additional information
?
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HpOCH1 is the key enzyme responsible for initiating N-linked outer chain biosynthesis by adding the first alpha-1,6-mannose residue onto the core oligosaccharide
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?
additional information
?
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enzyme initiates outer chain formation of oligosaccharides
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?
additional information
?
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Och1p is functional in the initiation of alpha-1,6-polymannose outer chain addition to the N-linked core oligosaccharide in yeast, Man5GlcNAc2 and Man8GlcNAc2
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?
additional information
?
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Mnn9p is required for the addition of the long alpha-1,6-mannose backbone of the complex mannan and for the complex glycosylation of secreted proteins
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?
additional information
?
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OCH1 gene encoded enzyme initiates the polymannose outer chain elongation of N-glycans, regulation of the OCH1 transcription
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?
additional information
?
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involved in glycoprotein biosynthesis, enzyme catalyzes the first step specific to N-linked oligosaccharide synthesis and the biosynthesis of the outer chain of mannoproteins
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?
additional information
?
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Och1p is essential for the outer chain elongation of N-linked oligosaccharides
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?
additional information
?
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Mnn9p is involved in the formation of mannan chains in the Golgi
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?
additional information
?
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Och1p is responsible for starting the extension of the primary N-glycans in the Golgi by addition of an alpha-1,6-mannose residue to the core glycan of glycoproteins
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?
additional information
?
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two distinct Mnn9p-containing multi-protein complexes are responsible for the synthesis and initial branching of the long alpha-1,6-linked backbone of the hypermannose structure attached to many yeast glycoproteins, the long alpha-1,6-linked backbone is attached to an initial alpha-1,6-mannose residue transferred to the core structure by Och1p
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?
additional information
?
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the N-linked oligosaccharide modification in the Golgi apparatus is initiated by alpha1,6-mannosyltransferase (encoded by the OCH1 gene) with the addition of mannose to the Man8GlcNAc2 or Man9GlcNAc2 endoplasmic reticulum intermediates
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?
additional information
?
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transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1-6)-D-mannosyl-D-mannose linkage
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-
?
additional information
?
-
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Mnn9p is required for the addition of the long alpha-1,6-mannose backbone of the complex mannan and for the complex glycosylation of secreted proteins
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-
?
additional information
?
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Och1p is functional in the initiation of alpha-1,6-polymannose outer chain addition to the N-linked core oligosaccharide in yeast, Man5GlcNAc2 and Man8GlcNAc2
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?
additional information
?
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OCH1 gene encoded enzyme initiates the polymannose outer chain elongation of N-glycans, regulation of the OCH1 transcription
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?
additional information
?
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Och1p is essential for the outer chain elongation of N-linked oligosaccharides
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?
additional information
?
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enzyme is required for the initiation of outer chain elongation of N-linked oligosaccharides of cell wall mannoproteins, transcriptional control of the och1+ gene, gene expression is not regulated during the cell cycle, but is induced by salt stress through the transcription factor Atf1p
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?
additional information
?
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SpOch1p is a key enzyme of outer chain elongation of N-linked oligosaccharides
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?
additional information
?
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SpOch1p is a key enzyme in outer chain elongation of N-linked oligosaccharides on glycoproteins
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?
additional information
?
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SpOch1p is a key enzyme in outer chain elongation of N-linked oligosaccharides on glycoproteins
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?
additional information
?
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enzyme is required for the initiation of outer chain elongation of N-linked oligosaccharides of cell wall mannoproteins, transcriptional control of the och1+ gene, gene expression is not regulated during the cell cycle, but is induced by salt stress through the transcription factor Atf1p
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?
additional information
?
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SpOch1p is a key enzyme of outer chain elongation of N-linked oligosaccharides
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-
?
additional information
?
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transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1-6)-D-mannosyl-D-mannose linkage
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?
