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2.4.1.229: [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
[Skp1-protein]-trans-4-hydroxy-L-proline
=
UDP
+
[Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycoprotein serine/threonine, acetylglucosaminyltransferase, uridine diphosphoacetylglucose-protein Skp1 hydroxyproline, Dd-ppGnT1, GnT1, GnT51, hydroxyproline-capping enzyme, Skp1 alpha-GlcNAcT1, Skp1 alpha-GlcNAcT1-like enzyme, Skp1-HyPro GlcNAc-transferase, UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.229 [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase

Engineering

Engineering on EC 2.4.1.229 - [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D102A
site-directed mutagenesis, no remaining activity
H104D
site-directed mutagenesis, no remaining activity
K23R
site-directed mutagenesis, unaltered enzyme activity
L276S
site-directed mutagenesis, 7% remaining activity compared to the wild-type enzyme
additional information
C-terminal deletion mutants GnT51(1-282) and GnT51(1-369+) show no remaining activity