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2.4.1.228: lactosylceramide 4-alpha-galactosyltransferase

This is an abbreviated version!
For detailed information about lactosylceramide 4-alpha-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.228

Reaction

UDP-alpha-D-galactose
+
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
=
UDP
+
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

A4GalT, alpha 1-4 galactosyltransferase, alpha1,4-galactosyltransferase, alpha1,4Gal-T, blood group P1 synthase, Gal-beta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-lactosylceramide, galactosyltransferase, uridine diphosphogalactose-lactosylceramide alpha1-4-, Gb3 galactosyltransferase, GB3 synthase, Gb3/CD77 synthase, Gb3Cer synthase, Gb3S, GCS, globotetraosyl ceramide synthase, globotriaosylceramide synthase, globotriaosylceramide/CD77 synthase, glucosylceramide synthase, histo-blood group Pk antigen synthase, histo-blood group Pk UDP-galactose, lactosylceramide 4-alpha-galactosyltransferase, lactosylceramide alpha1,4-galactosyltransferase, lactosylceramide alpha1,4galactosyltransferase, Pk synthase, UDP-galactose-lactosylceramide galactosyltransferase, UDP-galactose:beta-D-galactosyl-beta-1-R 4-alpha-D-galactosyltransferase, UDP-galactose:lactosylceramide alpha-galactosyltransferase, UDP-galactose:lactosylceramide alpha1-4-galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase

Reference

Reference on EC 2.4.1.228 - lactosylceramide 4-alpha-galactosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Taniguchi, N.; Yanagisawa, K.; Makita, A.; Naiki, M.
Purification and properties of rat liver globotriaosylceramide synthase, UDP-galactose:lactosylceramide alpha1-4-galactosyltransferase
J. Biol. Chem.
260
4908-4913
1985
Rattus norvegicus
Manually annotated by BRENDA team
Bailly, P.; Piller, F.; Cartron, J.P.; Leroy, Y.; Fournet, B.
Identification of UDP-galactose:lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney
Biochem. Biophys. Res. Commun.
141
84-91
1986
Homo sapiens
Manually annotated by BRENDA team
Iizuka, S.; Chen, S.H.; Yoshida, A.
Studies on the human blood group P system: an existence of UDP-Gal: lactosylceramide alpha 1 -> 4 galactosyltransferase in the small p type cells
Biochem. Biophys. Res. Commun.
137
1187-1195
1986
Homo sapiens
Manually annotated by BRENDA team
Chen, C.; Fenderson, B.A.; Andrews, P.W.; Hakomori, S.
Glycolipid glycosyltransferases in human embryonal carcinoma cells during retinoic acid induced differentiation
Biochemistry
28
2229-2238
1989
Homo sapiens
Manually annotated by BRENDA team
Stults, C.L.M.; Larsen, R.D.; Macher, B.A.
alpha-1,4Galactosyltransferase activity and Gbeta3Cer expression in human leukemia/lymphoma cell lines
Glycoconj. J.
12
680-689
1995
Homo sapiens
Manually annotated by BRENDA team
Mobassaleh, M.; Koul, O.; Mishra, K.; McCluer, R.H.; Keusch, G.T.
Developmentally regulated Gb3 galactosyltransferase and alpha-galactosidase determine Shiga toxin receptors in intestine
Am. J. Physiol.
267
G618-G624
1994
Oryctolagus cuniculus
Manually annotated by BRENDA team
Kojima, Y.; Fukumoto, S.; Furukawa, K.; Okajima, T.; Wiels, J.; Yokoyama, K.; Suzuki, Y.; Urano, T.; Ohta, M.; Furukawa, K.
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of Globo series glycosphingolipids
J. Biol. Chem.
275
15152-15156
2000
Homo sapiens
Manually annotated by BRENDA team
Steffensen, R.; Carlier, K.; Wiels, J.; Levery, S.B.; Stroud, M.; Cedergren, B.; Sojka, B.N.; Bennett, E.P.; Jersild, C.; Clausen, H.
Cloning and expression of the histo-blood group Pk UDP-galactose: Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype
J. Biol. Chem.
275
16723-16729
2000
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team
Iwamura, K.; Furukawa, K.; Uchikawa, M.; Sojka, B.N.; Kojima, Y.; Wiels, J.; Shiku, H.; Urano, T.; Furukawa, K.
The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene: a clue to the solution of the P1/P2/p puzzle
J. Biol. Chem.
278
44429-44438
2003
Homo sapiens
Manually annotated by BRENDA team
Okuda, T.; Tokuda, N.; Numata, S.; Ito, M.; Ohta, M.; Kawamura, K.; Wiels, J.; Urano, T.; Tajima, O.; Furukawa, K.; Furukawa, K.
Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
J. Biol. Chem.
281
10230-10235
2006
Mus musculus
Manually annotated by BRENDA team
Okuda, T.; Nakayama, K.I.
Identification and characterization of the human Gb3/CD77 synthase gene promoter
Glycobiology
18
1028-1035
2008
Homo sapiens
Manually annotated by BRENDA team
Schweppe, C.H.; Bielaszewska, M.; Pohlentz, G.; Friedrich, A.W.; Buentemeyer, H.; Alexander Schmidt, M.; Kim, K.S.; Peter-Katalini?, J.; Karch, H.; Muething, J.
Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity
Glycoconj. J.
25
291-304
2008
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team
Shin, I.S.; Ishii, S.; Shin, J.S.; Sung, K.I.; Park, B.S.; Jang, H.Y.; Kim, B.W.
Globotriaosylceramide (Gb3) content in HeLa cells is correlated to Shiga toxin-induced cytotoxicity and Gb3 synthase expression
BMB Rep.
42
310-314
2009
Homo sapiens
Manually annotated by BRENDA team
Okuda, T.; Furukawa, K.; Nakayama, K.
A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis
FEBS J.
276
5191-5202
2009
Homo sapiens
Manually annotated by BRENDA team
Ramkumar, S.; Sakac, D.; Binnington, B.; Branch, D.R.; Lingwood, C.A.
Induction of HIV-1 resistance: cell susceptibility to infection is an inverse function of globotriaosyl ceramide levels
Glycobiology
19
76-82
2009
Homo sapiens
Manually annotated by BRENDA team
Shiozuka, C.; Taguchi, A.; Matsuda, J.; Noguchi, Y.; Kunieda, T.; Uchio-Yamada, K.; Yoshioka, H.; Hamanaka, R.; Yano, S.; Yokoyama, S.; Mannen, K.; Kulkarni, A.B.; Furukawa, K.; Ishii, S.
Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease
J. Biochem.
149
161-170
2011
Homo sapiens
Manually annotated by BRENDA team
Yamaji, T.; Nishikawa, K.; Hanada, K.
Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis
J. Biol. Chem.
285
35505-35518
2010
Homo sapiens
Manually annotated by BRENDA team
Suchanowska, A.; Kaczmarek, R.; Duk, M.; Lukasiewicz, J.; Smolarek, D.; Majorczyk, E.; Jaskiewicz, E.; Laskowska, A.; Wasniowska, K.; Grodecka, M.; Lisowska, E.; Czerwinski, M.
A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome
J. Biol. Chem.
287
38220-38230
2012
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team
Kaczmarek, R.; Duk, M.; Szymczak, K.; Korchagina, E.; Tyborowska, J.; Mikolajczyk, K.; Bovin, N.; Szewczyk, B.; Jaskiewicz, E.; Czerwinski, M.
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating Pk, P1 and NOR blood group antigens
Biochem. Biophys. Res. Commun.
470
168-174
2016
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team
Tyler, A.; Johansson, A.; Karlsson, T.; Gudey, S.K.; Braennstroem, T.; Grankvist, K.; Behnam-Motlagh, P.
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells
Exp. Cell Res.
336
23-32
2015
Homo sapiens
Manually annotated by BRENDA team
Jacob, F.; Alam, S.; Konantz, M.; Liang, C.Y.; Kohler, R.S.; Everest-Dass, A.V.; Huang, Y.L.; Rimmer, N.; Fedier, A.; Schoetzau, A.; Lopez, M.N.; Packer, N.H.; Lengerke, C.; Heinzelmann-Schwarz, V.
Transition of mesenchymal and epithelial cancer cells depends on alpha1-4 galactosyltransferase-mediated glycosphingolipids
Cancer Res.
78
2952-2965
2018
Homo sapiens (Q9NPC4)
Manually annotated by BRENDA team
Kaczmarek, R.; Mikolajewicz, K.; Szymczak, K.; Duk, M.; Majorczyk, E.; Krop-Watorek, A.; Buczkowska, A.; Czerwinski, M.
Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase
Glycoconj. J.
33
963-973
2016
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team
Lv, X.; Chen, Y.; Luo, Y.; Li, L.; Wang, H.
The synonymous 903C>G mutation in the alpha 1,4-galactosyltransferase gene in a Chinese woman with habitual abortion A case report
Medicine (Baltimore)
98
e16361
2019
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team
Kaczmarek, R.; Szymczak-Kulus, K.; Bereznicka, A.; Mikolajczyk, K.; Duk, M.; Majorczyk, E.; Krop-Watorek, A.; Klausa, E.; Skowronska, J.; Michalewska, B.; Brojer, E.; Czerwinski, M.
Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system
PLoS ONE
13
e0196627
2018
Homo sapiens (Q9NPC4), Homo sapiens
Manually annotated by BRENDA team