2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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For detailed information about glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.223

2.4.1.223

heparan

proteoglycans

glycosyltransferases

ext-like

glycosaminoglycans

extls

chondroitin

exostosins

mucous

n-acetylgalactosamine

tetrasaccharide

wingless

decapentaplegic

brunner

heparitinase

pancreaticobiliary

hspgs

fam20b

Reaction

[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

[protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Exostosin-like 2, EXTL2, EXTL3, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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Results	in table
37	AA Sequence
2	CAS Registry Number
4	Cloned(Commentary)
43	Disease/ Diagnostics
4	Expression
2	General Information
1	Inhibitors
3	Localization
4	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
4	PDB ID
2	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
10	Reference
11	Source Tissue
20	Substrates and Products (Substrate)
11	Synonyms
1	Systematic Name
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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UDP-N-acetyl-alpha-D-glucosamine:[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 4IV-alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining)

Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. Apparently products of both the human EXTL2 and EXTL3 genes can catalyse this reaction. In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase. For explanation of the use of a superscript in the systematic name, see {iupac/2carb/37#372::2-Carb-37.2}.