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2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.223

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
 +
[protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Exostosin-like 2, EXTL2, EXTL3, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

Substrates Products

Substrates Products on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
show the reaction diagram
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + alpha-thrombomodulin
UDP + alpha-N-acetyl-D-glucosaminyl-alpha-thrombomodulin
show the reaction diagram
-
55% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-beta-O-Ser-Gly-Trp-Pro-Asp-Gly
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-beta-O-Ser-Gly-Trp-Pro-Asp-Gly
show the reaction diagram
-
-
18% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
show the reaction diagram
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
show the reaction diagram
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol
show the reaction diagram
-
28% of the rate with UDP-N-acetyl-D-galactosamine
-
-
?
UDP-N-acetyl-D-glucosamine + glypican-1
UDP + alpha-N-acetyl-D-glucosaminyl-glypican-1
show the reaction diagram
-
30% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
-
?
additional information
?
-