2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Exostosin-like 2, EXTL2, EXTL3, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
37	AA Sequence
2	CAS Registry Number
4	Cloned(Commentary)
43	Disease/ Diagnostics
4	Expression
2	General Information
1	Inhibitors
3	Localization
4	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
4	PDB ID
2	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
10	Reference
11	Source Tissue
20	Substrates and Products (Substrate)
11	Synonyms
1	Systematic Name
1	Temperature Stability [°C]

Disease

topprint

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Disease on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

Please use the Disease Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adenocarcinoma

A novel endo-beta-galactosidase from Clostridium perfringens that liberates the disaccharide GlcNAcalpha 1-->Gal from glycans specifically expressed in the gastric gland mucous cell-type mucin.

11382776

Carcinogenesis

Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.

32347583

Demyelinating Diseases

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.

32703234

Exostoses, Multiple Hereditary

Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.

17237233

Exostoses, Multiple Hereditary

rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.

11121397

glucuronosyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase deficiency

Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.

32347583

Kashin-Beck Disease

Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

32517548

Mucopolysaccharidoses

Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.

19690583

Mucopolysaccharidosis III

Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.

19690583

Neoplasms

Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.

32347583

Neoplasms

Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.

17237233

Neoplasms

EXTL2, a Member of the EXT Family of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner.

23395820

Neoplasms

rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.

11121397

Neoplasms

Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes.

23734945

Neoplasms

The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.

10318803

Neuroinflammatory Diseases

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.

32703234

Osteoarthritis

Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

32517548

Pancreatic Neoplasms

Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer.

16441422

Stomach Neoplasms

Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer.

12594234

html completed