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2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.223

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
+
[protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Exostosin-like 2, EXTL2, EXTL3, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

Cloned

Cloned on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Cos-1 cells
expression in COS-1 cells, lacking the putative NH2-terminal transmembrane and cytoplasmic domains
-
expression in COS-1 cells, truncated form , lacking the first 58 N-terminal amino acids
-
human lumenal N-glycosylated EXTL3 (EXTL3DELTAN) is cloned, expressed in human embryonic kidney cells