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2.4.1.222: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.222

Reaction

UDP-beta-D-GlcNAc
+
PCQNGGS(O-beta-L-fucosyl)-CKDQL
=
UDP
 +
PCQNGGS(O-D-GlcNAcbeta(1-3)-L-Fucbeta)-CKDQL

Synonyms

acetylglucosaminylferase, uridine diphosphoacetylglucosamine:fucosyglycoprotein beta1-3-, beta-1,3-N-acetyl-glucosaminyltransferase, beta-1,3-N-acetylglucosaminyltransferase, beta1,3-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-2, beta1,3-N-acetylglusoaminyltransferase, Dfng, FNG, Fringe, fringe beta1,3 N-acetylglucosaminyltransferase, fringe glycosyltransferase, Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferase, Fringe protein, glycosyltransferase Fringe, LFNG, Lunatic Fringe, lunatic fringe glycosyltransferase, Maniac Fringe, Manic fringe, manic fringe glycosyltransferase, MFng, N-acetylglucosaminyltransferase, O-fucose-beta1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide-3-beta-N-acetylglucosaminyltransferase, Radical Fringe, radical fringe glycosyltransferase, Rfng, UDP-acetylglucosamine:fucosylglycoprotein, UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase, UDP-GlcNAc:fucose beta1,3 N-acetylglucosaminyltransferase, UDP-glucose:O-linked fucose beta1,3-glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.222 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Cloned

Cloned on EC 2.4.1.222 - O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain of murine Manic Fringe is expressed in the baculovirus/insect-cell system as a secreted protein
coexpression of Flag-tagged DLL3 and HA-tagged LFNG in CHO cells, the two proteins coprecipitate
DNA acid sequence determination and analysis, expression as insoluble His-tagged protein in Escherichia coli strain XL1-Blue
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expressed in Drosophila S2 cells
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expression of MFeng as soluble protein in fusion with galectin-1 from pLgals1-hum-MFng in Escherichia coli Rosetta (DE3) pLysS
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expression of Radical Fringe, Lunatic Fringe, and Manic Fringe in HEK 293T cells and NIH 3T3 cells
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full-length, His-tagged FNG is expressed in S2 cells from a pMTHy vector construct
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gene fng, DNA and amino acid sequence determination and analysis
gene Lfng, Lfng is located at 7p22 arm of human chromosome
gene LFNG, quantitative RT-PCR enzyme expression analysis
gene Mfng, Mfng maps to human chromosome 22q13.1
gene Rfng, Rfng is localized at 17q25 arm of human chromosome
genes lfng and mfng, expression in wild-type CHO cells, in Lec1.3C, Lec2.6A, Lec8.3D, and Lec20.15C CHO glycosylation mutant lines, and in Lec8 and Lec20 CHO mutant lines
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Lfng overexpression in transgenic mouse model
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Lunatic Fringe and Manic Fringe expressed in Chinese hamster ovary Lec1 cells
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Manic Fringe stable expressed in Chinese hamster ovary Lec1 cells
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mouse FRINGE coding sequences are ligated into pcDNA3 for transfection of NIH3T3 cells
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Notch alone or Fringe alone expressed in Drosophila SL2 cells or Notch and Fringe co-expressed in Drosophila SL2 cells
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overexpression in S2 cells
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