2.4.1.217: mannosyl-3-phosphoglycerate synthase
This is an abbreviated version!
For detailed information about mannosyl-3-phosphoglycerate synthase, go to the full flat file.
Word Map on EC 2.4.1.217
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2.4.1.217
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mannosylglycerate
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cavernous
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d-3-phosphoglycerate
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osmoadaptation
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intracavernosal
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supra-annular
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bioprostheses
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neurography
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thermoadaptation
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patient-prosthesis
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rhodothermus
- 2.4.1.217
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mannosylglycerate
-
cavernous
- d-3-phosphoglycerate
-
osmoadaptation
-
intracavernosal
-
supra-annular
-
bioprostheses
-
neurography
-
thermoadaptation
-
patient-prosthesis
-
rhodothermus
Reaction
Synonyms
mannosyl-3-P-glycerate synthase, mannosyl-3-phosphoglycerate phosphatase, mannosyl-3-phosphoglycerate synthase, mannosyl-3-phosphoglycerate synthase/phosphatase, mannosylglycerate synthase, MGSD, MPG synthase, MPGP, MPGS, MPGS/GPGS, MpgS/P, synthase, mannosyl-3-phosphoglycerate
ECTree
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Reaction
Reaction on EC 2.4.1.217 - mannosyl-3-phosphoglycerate synthase
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GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate
the enzyme is bifunctional exhibiting both mannosyl-3-phosphoglycerate synthase, EC 2.4.1.217, and mannosyl-3-phosphoglycerate phosphatase, EC 3.1.3.70, activities, catalyzing the consecutive synthesis and dephosphorylation of mannosyl-3-phosphoglycerate in mannosylglycerate biosynthesis
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GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate
front-face SNi-like reaction mechanism, detailed overview. The binding of GDP-mannose:Mn2+ to the enzyme from Rhodothermus marinus induces significant conformational changes in the flexible loop. In particular, Tyr220 plays a pivotal role both in D-glycerate binding and in catalysis: it is reoriented towards the pocket interior and either interacts with the a phosphate of GDP-mannose
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GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate
front-face SNi-like reaction mechanism, overview
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GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate
front-face SNi-like reaction mechanism, overview
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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