2.4.1.212: hyaluronan synthase

This is an abbreviated version!
For detailed information about hyaluronan synthase, go to the full flat file.

Word Map on EC 2.4.1.212

2.4.1.212

glycosaminoglycans

collagen

polysaccharide

keratinocytes

cartilage

4-methylumbelliferone

proteoglycans

hyaluronidases

chondrocytes

dermal

mesenchymal

pericellular

pasteurella

udp-glucuronic

hyals

versican

cumulus

synovial

vocal

articular

aggrecan

osteoarthritis

streptococcal

udp-n-acetylglucosamine

multocida

rhamm

pyogenes

udp-sugars

chondroitin

glucuronic

procollagen

synoviocytes

cumulus-oocyte

decorin

udp-glcua

photoaging

filaggrin

equisimilis

ha-binding

temporomandibular

glcua

perineuronal

ophthalmopathy

zooepidemicus

uvb-irradiated

ha-mediated

tnfaip6

medicine

hyaluronan-binding

fibromodulin

biglycan

analysis

synthesis

drug development

biotechnology

Reaction

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

Synonyms

CHAS2, CHAS3, class I hyaluronan synthase, CPS1, DG42 protein, HA synthase, HA synthase 3, HA1, HA2, HA3, HAS, HAS-1, HAS-2, HAS-3, HAS1, Has2, Has3, hasA, HASs, HsHAS1, HuHAS1, HyaD, hyaluronan synthase, hyaluronan synthase 1, hyaluronan synthase 2, hyaluronan synthase 3, hyaluronan synthase-1, hyaluronan synthase-2, hyaluronan synthases 2, hyaluronan synthethase, hyaluronate synthase, hyaluronate synthetase, hyaluronic acid synthase, hyaluronic acid synthetase, More, PmHAS, seHAS, XHAS1, XHAS2, XHAS3

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.212 hyaluronan synthase

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Results	in table
47	Activating Compound
2738	AA Sequence
22	Application
1	CAS Registry Number
66	Cloned(Commentary)
687	Disease/ Diagnostics
24	Expression
51	General Information
2	General Stability
57	Inhibitors
4	Ki Value [mM]
71	KM Value [mM]
60	Localization
28	Metals/Ions
13	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
340	Organism
19	pH Optimum
2	pH Range
2	pH Stability
10	Posttranslational Modification
125	Protein Variants
14	Purification (Commentary)
14	Reaction
20	Reaction Type
129	Reference
144	Source Tissue
38	Specific Activity [micromol/min/mg]
1	Storage Stability
139	Substrates and Products (Substrate)
13	Subunits
202	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 2.4.1.212 - hyaluronan synthase

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Co2+

2 entries

K+

Pasteurella multocida

Q7BLV3

coactivation occurs if K+ is applied together with Mn2+ or Mg2+. With Mn2+, a high UDP reaction rate and high molecular mass of hyaluronic acid (2.45 MDa after 8 h) are achieved. With Mg2+, a low reaction rate and low molecular mass (1.55 MDa after 8 h) are reached. If 10 mM K+ are added to 15 mM Mg2+, a significant increase of the reaction rate by a factor of 2.7 is observed, and the molecular mass is doubled (3.11 MDa after 8 h). The coactivating effect of K+ together with Mn2+ is less pronounced

756468

KCl

Streptococcus dysgalactiae subsp. equisimilis

activates at 50 mM, slightly more effective than NaCl

658093

Mg2+

16 entries

Mn2+

5 entries

NaCl

Streptococcus dysgalactiae subsp. equisimilis

activates at 50 mM, slightly less effective than KCl

658093

additional information

Pasteurella multocida

metal requirements of mutant enzymes, overview

658841