2.4.1.212: hyaluronan synthase
This is an abbreviated version!
For detailed information about hyaluronan synthase, go to the full flat file.
Word Map on EC 2.4.1.212
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2.4.1.212
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glycosaminoglycans
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collagen
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polysaccharide
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keratinocytes
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cartilage
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4-methylumbelliferone
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proteoglycans
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hyaluronidases
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chondrocytes
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dermal
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mesenchymal
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pericellular
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pasteurella
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udp-glucuronic
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hyals
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versican
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cumulus
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synovial
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vocal
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articular
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aggrecan
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osteoarthritis
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streptococcal
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udp-n-acetylglucosamine
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multocida
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rhamm
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pyogenes
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udp-sugars
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chondroitin
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glucuronic
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procollagen
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synoviocytes
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cumulus-oocyte
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decorin
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udp-glcua
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photoaging
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filaggrin
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equisimilis
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ha-binding
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temporomandibular
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glcua
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perineuronal
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ophthalmopathy
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zooepidemicus
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uvb-irradiated
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ha-mediated
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tnfaip6
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medicine
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hyaluronan-binding
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fibromodulin
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biglycan
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analysis
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synthesis
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drug development
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biotechnology
- 2.4.1.212
- glycosaminoglycans
- collagen
- polysaccharide
- keratinocytes
- cartilage
- 4-methylumbelliferone
- proteoglycans
- hyaluronidases
- chondrocytes
-
dermal
- mesenchymal
-
pericellular
- pasteurella
-
udp-glucuronic
-
hyals
- versican
-
cumulus
- synovial
-
vocal
-
articular
- aggrecan
- osteoarthritis
- streptococcal
- udp-n-acetylglucosamine
- multocida
-
rhamm
- pyogenes
- udp-sugars
- chondroitin
-
glucuronic
- procollagen
- synoviocytes
-
cumulus-oocyte
- decorin
- udp-glcua
-
photoaging
- filaggrin
- equisimilis
-
ha-binding
-
temporomandibular
-
glcua
-
perineuronal
- ophthalmopathy
- zooepidemicus
-
uvb-irradiated
-
ha-mediated
-
tnfaip6
- medicine
-
hyaluronan-binding
- fibromodulin
- biglycan
- analysis
- synthesis
- drug development
- biotechnology
Reaction
Synonyms
CHAS2, CHAS3, class I hyaluronan synthase, CPS1, DG42 protein, HA synthase, HA synthase 3, HA1, HA2, HA3, HAS, HAS-1, HAS-2, HAS-3, HAS1, Has2, Has3, hasA, HASs, HsHAS1, HuHAS1, HyaD, hyaluronan synthase, hyaluronan synthase 1, hyaluronan synthase 2, hyaluronan synthase 3, hyaluronan synthase-1, hyaluronan synthase-2, hyaluronan synthases 2, hyaluronan synthethase, hyaluronate synthase, hyaluronate synthetase, hyaluronic acid synthase, hyaluronic acid synthetase, More, PmHAS, seHAS, XHAS1, XHAS2, XHAS3
ECTree
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Activating Compound
Activating Compound on EC 2.4.1.212 - hyaluronan synthase
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black rice hydrolized peptides
BRP from germinated Oryza sativa L. var. japonica
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dioleoyl phosphatidic acid
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stimulates about 10fold
ERK
heregulin-mediated HAS isozyme phosphorylation/activation
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O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
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increases O-GlcNAcylation and HA synthesis
phorbol 12-myristate 13-acetate
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activation of enzyme in plasma membrane fraction
platelet-derived growth factor BB
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activation of enzyme in plasma membrane fraction
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tunicamycin
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significant increase in HAS activity in the cytosolic membrane fraction after tunicamycin treatment
the bacterial enzyme is strictly associated with cardiolipin and the catalytic activity is dependent on such lipid
cardiolipin
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required for full activity, activates up to 10fold, 14-18 molecules of cardiolipin are bound to one molecule of enzyme
cardiolipin
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the bacterial enzyme is strictly associated with cardiolipin and the catalytic activity is dependent on such lipid
tetraoleoyl cardiolipin
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strong activation, same pattern of lipid preference between pH 6 and 10.5. Lipid-independent activity at pH 11.5
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HAS2 can be O-GlcNAcylated on serine 221, which strongly increases its activity and its stability to half-life of over 5 h versus 17 min without O-GlcNAcylation
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additional information
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the isozymes use cytoplasmic UDP-GlcNAc and UDP-GlcUA as precursors to polymerize the hyaluronan chain and to extrude it out of the cell without the necessity of a primer or an anchor protein or lipid
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additional information
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progesterone activates the expression of HAS3, low-molecular-weight hyaluronan activates the expression of isozyme HAS1
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additional information
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enzyme is more active in 25 mM phosphate buffer than in 50 mM
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additional information
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tetramyristoyl cardiolipin is ineffective in activation
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