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2.4.1.212: hyaluronan synthase

This is an abbreviated version!
For detailed information about hyaluronan synthase, go to the full flat file.

Word Map on EC 2.4.1.212

Reaction

UDP-alpha-D-glucuronate
+
N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
=
UDP
+
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

Synonyms

CHAS2, CHAS3, class I hyaluronan synthase, CPS1, DG42 protein, HA synthase, HA synthase 3, HA1, HA2, HA3, HAS, HAS-1, HAS-2, HAS-3, HAS1, Has2, Has3, hasA, HASs, HsHAS1, HuHAS1, HyaD, hyaluronan synthase, hyaluronan synthase 1, hyaluronan synthase 2, hyaluronan synthase 3, hyaluronan synthase-1, hyaluronan synthase-2, hyaluronan synthases 2, hyaluronan synthethase, hyaluronate synthase, hyaluronate synthetase, hyaluronic acid synthase, hyaluronic acid synthetase, More, PmHAS, seHAS, XHAS1, XHAS2, XHAS3

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.212 hyaluronan synthase

Activating Compound

Activating Compound on EC 2.4.1.212 - hyaluronan synthase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
black rice hydrolized peptides
BRP from germinated Oryza sativa L. var. japonica
-
carbocyclic thromboxane A2
-
-
cardiolipin
dioleoyl phosphatidic acid
-
stimulates about 10fold
Epidermal growth factor
-
EGF
Epstein-Barr virus
-
-
-
ERK
heregulin-mediated HAS isozyme phosphorylation/activation
-
interleukin 1beta
-
activation of enzyme in plasma membrane fraction
-
interleukin-1beta
-
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate
-
increases O-GlcNAcylation and HA synthesis
PDGF-BB
-
-
-
phorbol 12-myristate 13-acetate
-
activation of enzyme in plasma membrane fraction
pinane thromboxane A2
-
-
platelet derived growth factor BB
-
platelet derived growth factor-BB
-
PDGF-BB
-
platelet-derived growth factor BB
-
activation of enzyme in plasma membrane fraction
-
prostacyclin
-
-
prostaglandin E2
prostaglandin F2alpha
-
-
prostaglandin I2
synthetic single-stranded poly(A)
-
-
-
synthetic single-stranded poly(C)
-
-
-
synthetic viral RNA analog poly(I,C)
-
-
-
tetraoleoyl cardiolipin
TGFbeta1
-
-
-
TNFalpha
-
-
-
Transforming growth factor
-
TGF-1beta
-
transforming growth factor-beta
-
TGF-beta
-
transforming growth factor-beta1
-
TGF-beta1
-
tunicamycin
-
significant increase in HAS activity in the cytosolic membrane fraction after tunicamycin treatment
UVB irradiation
-
additional information
-