2.4.1.210: limonoid glucosyltransferase
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For detailed information about limonoid glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.210
Reaction
Synonyms
CitLGT-1, CitLGT-2, CrLGT, cuGT, LGT, LGTase, limonoid glucosyltransferase, limonoid GTase, limonoid UDP glucosyltransferase, limonoid UDP-glucosyltransferase, SLLGT, UDP-D-glucose:limonoid glucosyltransferase, UDP-glucose:limonoid glucosyltransferase
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General Information on EC 2.4.1.210 - limonoid glucosyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
malfunction
overexpression of the LGT gene can reduce the delayed bitterness problem in citrus juice and enhance the accumulation of specific glucosides that have anticancer effects
metabolism
physiological function
limonoid glucosyltransferase (LGT) is a natural debittering enzyme, because the delayed bitterness problem is caused mainly by limonoid aglycones such as limonin. THe product of LGT reaction, limonin 17-beta-D-glucopyranoside, in non-bitter and has anticancer potential in animals including humans
additional information
evolution
the enzyme belongs to clade C of flavonoid and limonoid glucosyltransferases
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview. Limonoid glucosyltransferases belong to the family of glycosyltransferases. Two alleles (CitLGT1/ CitLGT2) of LGT at a single locus which are related to the dexadlayed bitterness in Citrus. The CitLGT2 differs from CitLGT1 by 15 nucleotide substitutions and these subxadstitutions are scattered throughout the coding region of the gene
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview. Limonoid glucosyltransferases belong to the family of glyxadcosyltransferases
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview. Limonoid glucosyltransferases belong to the family of glyxadcosyltransferases
evolution
limonoids are highly oxygenated triterpenes present mostly in Rutaceae and other limited plants of Meliaceae and Simaroubaceae, tissue distribution, overview. Limonoid glucosyltransferases belong to the family of glyxadcosyltransferases
evolution
the enzyme belongs to the superfamily PLN03004 (UDP-glycosyltransferase). Citrus reticulata limonoid glucosyltransferase (CrLGT) occupies a position on an independent branch in the largest subgroup and is phylogenetically different from those in other mandarin species like Citrus unshiu, showing its uniqueness in several features
metabolism
enzyme LGT is important in the limonoid metabolism pathway in Citrus plants. Limonoid glucosyltransfease (LGT) is the only single regulatory enzyme that is able to convert all limonoid aglycones such as nomilin, obacunone, and ichangin present in Citrus spp. to their respective glucosides, in addition to limonoate A-ring lactone (LARL) to limonin glucopyranoside. During juicing process bitter limonin is immediately produced from LARL precursor by limonin D-ring lactone hydrolase (LLH) regulatory enzyme, especially in early to mid-stage developed Citrus fruits
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
metabolism
limonoid glucosyltransferase (LGT) is a regulatory enzyme in the citrus limonoid biosynthetic pathway. Limonoid biosynthesis in plants, overview
additional information
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limonoid glucosyltransferase is an enzyme that catalyzes the conversion of bitter limonoid into non-bitter limonoid glucoside while retaining the health benefit of limonoids in the juice
additional information
inhibition of the enzyme acxadtivity by Cu2+ and Hg2+ ions suggests that thiol, carboxyl groups or histidine residues are directly or indirectly involved in the catalytic mechanism of the LGT enzyme. Inhibitory efxadfect of citraconic anhydride suggests the lysine or arginine may be involved in catalytic activity of pummelo LGT
