2.4.1.208: diglucosyl diacylglycerol synthase (1,2-linking)

This is an abbreviated version!
For detailed information about diglucosyl diacylglycerol synthase (1,2-linking), go to the full flat file.

Reaction

Synonyms

1,2-diacylglycerol-3-alpha-glucosyl transferase, DGlcDAG synthase, diglucosyldiacylglycerol synthase, glucosyltransferase, uridine diphosphoglucose-monoglucosyldiacylglycerol, MgGlcDAG (1->2) glucosyltransferase, monoglucosyl diacylglycerol (1->2) glucosyltransferase, monoglucosyldiacylglycerol glucosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.208 diglucosyl diacylglycerol synthase (1,2-linking)

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Results	in table
29	Activating Compound
33	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	General Stability
6	Inhibitors
2	KM Value [mM]
3	Localization
3	Metals/Ions
8	Natural Substrates/ Products (Substrates)
34	Organism
3	Pathway
2	pH Optimum
1	Purification (Commentary)
3	Reaction
1	Reaction Type
12	Reference
1	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
24	Substrates and Products (Substrate)
10	Synonyms
1	Systematic Name

Activating Compound

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of the Enzyme Summary Page.

Activating Compound on EC 2.4.1.208 - diglucosyl diacylglycerol synthase (1,2-linking)

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,2-dioleoylphosphatidylethanolamine

Acholeplasma laidlawii

-

maximal activity at 4.5%

488887

1,2-dioleoylphosphatidylglycerol

3 entries

1,2-dioleoylphosphatidylserine

Acholeplasma laidlawii

-

33% of activation with 1,2-dioleoylphosphatidylglycerol

488887

1,3-diacylglycerol

Acholeplasma laidlawii

-

-

488886

1,3-dioleoylglycerol

Acholeplasma laidlawii

-

11.5 mol%, 5fold activation

488887

ATP

Acholeplasma laidlawii

-

approx. 12fold stimulation at 0.75 mM, inhibition above 1.5 mM

488888

cardiolipin

2 entries

diphosphatidylglycerol

Acholeplasma laidlawii

-

from bovine, 50% of activation with 1,2-dioleoylphosphatidylglycerol

488887

dsDNA

Acholeplasma laidlawii

-

0.0007 mg/ml, 7fold activation

488888

-

fructose-1,6-bisphosphate

Acholeplasma laidlawii

-

1 mM, approx. 18fold stimulation

488888

Lipid

3 entries

phosphate

3 entries

phosphatidylglycerol

4 entries

phosphatidylinositol

Acholeplasma laidlawii

-

strong activation in the presence of 1,2-dioleoylphosphatidylglycerol

488888

phosphatidylinositol-4,5-bisphosphate

Acholeplasma laidlawii

-

strong activation in the presence of 1,2-dioleoylphosphatidylglycerol

488888

phosphoenolpyruvate

Acholeplasma laidlawii

-

0.5 mM, 4fold stimulation, inhibition above 1.5 mM

488888

sn-glycero-1-phosphate

Acholeplasma laidlawii

-

stimulates above 15 mM

488888

additional information

2 entries

-

1,2-dioleoylphosphatidylglycerol

Acholeplasma laidlawii

-

-

488887

1,2-dioleoylphosphatidylglycerol

Acholeplasma laidlawii

-

maximal activation at 25 mol%

488890

1,2-dioleoylphosphatidylglycerol

Streptococcus pneumoniae

-

maximal activation at 30 mol%

488890

cardiolipin

Acholeplasma laidlawii

-

very strong stimulation in the presence of 1,3-dioleoylglycerol

488890

cardiolipin

Acholeplasma laidlawii

-

no endogenous compound of strain A-EF22

661626

Lipid

Acholeplasma laidlawii

-

activates

488885

Lipid

Acholeplasma laidlawii

-

activity is influenced in a dose-dependent manner by the nonbilayer propensities of several amphiphilic and hydrophilic lipids in two different bilayer matrices

488885

Lipid

Acholeplasma laidlawii

-

activation by non-lamellar forming lipids

488886

phosphate

Acholeplasma laidlawii

-

-

488890

phosphate

Acholeplasma laidlawii

-

40 mM, approx. 8fold activation

488887

phosphate

Acholeplasma laidlawii

-

20 mM, 5fold stimulation in the presence of 5 mM Mg2+

488888

phosphatidylglycerol

Acholeplasma laidlawii

-

-

661626

phosphatidylglycerol

Acholeplasma laidlawii

-

liquid-crystalline phosphatidylglycerol

488885

phosphatidylglycerol

Acholeplasma laidlawii

-

enzyme needs a polar activator lipid, preferably phosphatidylglycerol at concentrations of 25-30 mol% in zwitterionic mixed CHAPS bilayer-like aggregates

488887

phosphatidylglycerol

Acholeplasma laidlawii

-

in vivo amounts are not enough for efficient diglucosyldiacylglycerol synthesis

488888

additional information

Acholeplasma laidlawii

-

the enzyme is made from 1,2-diacylglycerol-3-glucosyltransferase, EC 2.4.1.157, in membranes with more unsaturated or longer acyl chains, increased temperature or increased amount of cholesterol

661626

-

additional information

Streptococcus pneumoniae

-

not activated by cardiolipin

488890

-