2.4.1.206: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

This is an abbreviated version!
For detailed information about lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide beta-, beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide synthase, beta1,3-N-acetylglucosaminyltransferase-2, beta1-3-N-acetylglucosaminyltransferase, beta3Gn-T2, beta3Gn-T5, beta3GnT5, GlcNAc transferase, LA2 synthase, LacCer(beta1,3)N-acetylglucosaminyltransferase, lactosylceramide beta-acetylglucosaminyltransferase, lactosylceramide: N-acetylglucosaminyltransferase, lactosylceramide:N-acetylglucosaminyltransferase, lactotriaosylceramide synthase, Lc2Cer-Glc-NAc-Tr, Lc3 synthase, Lc3 synthase/bGn-T5, UDP-GlcNAc:lactosylceramide beta1,3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.206 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

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Results	in table
12	Activating Compound
11	AA Sequence
1	Application
1	CAS Registry Number
10	Cloned(Commentary)
37	Disease/ Diagnostics
8	General Information
1	Inhibitors
3	KM Value [mM]
4	Localization
7	Metals/Ions
14	Natural Substrates/ Products (Substrates)
157	Organism
4	Pathway
5	pH Optimum
1	pH Range
2	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
17	Reference
61	Source Tissue
22	Specific Activity [micromol/min/mg]
40	Substrates and Products (Substrate)
26	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Disease

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Disease on EC 2.4.1.206 - lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Oncodevelopmental expression of--GlcNAc beta 1-6Man alpha 1-6Man beta 1--branched asparagine-linked oligosaccharides in murine tissues and human breast carcinomas.

2521456

Carcinoma

Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.

18483624

Carcinoma, Hepatocellular

Elevated activity of N-acetylglucosaminyltransferase V in human hepatocellular carcinoma.

9498831

Glioma

GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice.

19944071

Infections

Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.

18483624

Infections

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.

23955153

Neoplasm Metastasis

Organization of the human N-acetylglucosaminyltransferase V gene.

7588744

Neoplasms

Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis.

2953071

Neoplasms

Organization of the human N-acetylglucosaminyltransferase V gene.

7588744

Neoplasms

Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice.

21928695

Neuroblastoma

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

11042166

Salmonella Infections

Arginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium.

32504010

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