2.4.1.186: glycogenin glucosyltransferase

This is an abbreviated version!
For detailed information about glycogenin glucosyltransferase, go to the full flat file.

Reaction

Synonyms

CeGN, CgGN, CgGN-alpha, CgGN-beta, CgGN-gamma, EC 2.4.1.112, glucosyltransferase, uridine diphosphoglucose-protein, glucosyltransferase, uridine diphosphoglucose-protein 4-alpha-, glycogen initiator synthase, glycogenin, glycogenin 1, glycogenin 2, glycogenin glycosyltransferase, glycogenin-1, glycogenin-2, glyogenin, GN-1, GN1, GN2, GNN, GYG, GYG1, GYG2, hGYG1, M-glycogenin, priming glucosyltransferase, proglycogen synthase, UDP-glucose protein transglucosylase, UDP-glucose-protein glucosyltransferase, UDP-glucose:protein glucosyltransferase, UDPGlc:protein transglucosylase, UPTG, uridine diphosphate glucose-protein transglucosylase I, uridine diphosphoglucose protein transglucosylase I, uridine diphosphoglucose-protein 4-alpha-glucosyltransferase, uridine diphosphoglucose-protein glucosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.186 glycogenin glucosyltransferase

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Results	in table
1	Activating Compound
91	AA Sequence
6	Application
1	CAS Registry Number
23	Cloned(Commentary)
5	Crystallization (Commentary)
118	Disease/ Diagnostics
32	General Information
5	General Stability
17	Inhibitors
9	KM Value [mM]
5	Localization
14	Metals/Ions
17	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
48	Organism
3	Pathway
82	PDB ID
8	pH Optimum
1	pI Value
25	Posttranslational Modification
46	Protein Variants
15	Purification (Commentary)
15	Reaction
1	Reaction Type
45	Reference
67	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
110	Substrates and Products (Substrate)
24	Subunits
71	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
5	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.4.1.186 - glycogenin glucosyltransferase

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SYSTEMATIC NAME

IUBMB Comments

UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase

The first reaction of this enzyme is to catalyse its own glucosylation, normally at Tyr-194 of the protein if this group is free. When Tyr-194 is replaced by Thr or Phe, the enzyme's Mn2+-dependent self-glucosylation activity is lost but its intermolecular transglucosylation ability remains [7]. It continues to glucosylate an existing glucosyl group until a length of about 5--13 residues has been formed. Further lengthening of the glycogen chain is then carried out by EC 2.4.1.11, glycogen (starch) synthase. The enzyme is not highly specific for the donor, using UDP-xylose in addition to UDP-glucose (although not glucosylating or xylosylating a xylosyl group so added). It can also use CDP-glucose and TDP-glucose, but not ADP-glucose or GDP-glucose. Similarly it is not highly specific for the acceptor, using water (i.e. hydrolysing UDP-glucose) among others. Various forms of the enzyme exist, and different forms predominate in different organs. Thus primate liver contains glycogenin-2, of molecular mass 66 kDa, whereas the more widespread form is glycogenin-1, with a molecular mass of 38 kDa.