2.4.1.179: lactosylceramide beta-1,3-galactosyltransferase

This is an abbreviated version!
For detailed information about lactosylceramide beta-1,3-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

galactosyltransferase, uridine diphosphogalactose-lactosylceramide beta1-3-, GalT2, UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase, UDP-galactose:lactose beta1,3-galactosyltransferase, uridine diphosphogalactose-lactosylceramide beta1-3-galactosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.179 lactosylceramide beta-1,3-galactosyltransferase

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Results	in table
10	Activating Compound
1	CAS Registry Number
2	Cloned(Commentary)
2	General Stability
4	Inhibitors
6	KM Value [mM]
8	Localization
10	Metals/Ions
6	Natural Substrates/ Products (Substrates)
8	Organism
6	pH Optimum
3	pH Range
3	Purification (Commentary)
2	Reaction
1	Reaction Type
8	Reference
13	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
45	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.4.1.179 - lactosylceramide beta-1,3-galactosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-galactose + asialo-fetuin

UDP + beta-D-galactosyl-1,3-asialo-fetuin

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + asialo-glycophorin A

UDP + beta-D-galactosyl-1,3-asialo-glycophorin A

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + asialo-orosomucoid

UDP + beta-D-galactosyl-1,3-asialo-orosomucoid

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + beta-D-galactose

UDP + beta-D-galactosyl-1,3-beta-D-galactose

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine

UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosamine

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + beta-D-galactosyl-1,6-N-acetylglucosylamine

UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,6-N-acetylglucosylamine

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + beta-D-galactosyl-O-4-nitrophenyl

UDP + beta-D-galactosyl-1,3-beta-D-galactose-O-4-nitrophenyl

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucose

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

4 entries

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-glycolipid

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-glycolipid

2 entries

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

10 entries

UDP-galactose + ganglioside GM2

UDP + beta-D-galactosyl-1,3-ganglioside GM2

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + lacto-N-tetraose

UDP + beta-D-galactosyl-1,3-lacto-N-tetraose

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + lactosylceramide

?

2 entries

UDP-galactose + lactotriaosylceramide

UDP + lactotetraosylceramide

3 entries

UDP-galactose + lactulose

UDP + beta-D-galactosyl-1,3-lactulose

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + melibiose

UDP + beta-D-galactosyl-1,3-melibiose

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + methyl-alpha-galactoside

UDP + beta-D-galactosyl-1,3-methyl-alpha-galactoside

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + methyl-beta-galactoside

UDP + beta-D-galactosyl-1,3-methyl-beta-galactoside

2 entries

UDP-galactose + N-acetylgalactosamine

UDP + beta-D-galactosyl-1,3-N-acetylgalactosamine

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + N-acetyllactosamine

UDP + beta-D-galactosyl-1,3-N-acetyllactosamine

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + p-nitrophenyl-alpha-N-acetylgalactosylamine

UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-galactosylaminyl-4-nitrophenyl

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + stachyose

UDP + beta-D-galactosyl-1,3-stachyose

Notamacropus eugenii

-

-

638377

-

-

?

additional information

?

-

2 entries

UDP-galactose + D-galactosyl-1,4-beta-D-glucose

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

Homo sapiens

-

i.e. lactose

488980

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucose

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

Homo sapiens

-

i.e. lactose

638376

-

638376

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucose

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

Notamacropus eugenii

-

best substrate

638377

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucose

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucose

Notamacropus eugenii

-

i.e. lactose

638377

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-glycolipid

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-glycolipid

Homo sapiens

-

associated with biosynthesis of type 1 lactoseries core chain carbohydrate structure

638379, 638380, 638381

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-glycolipid

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-glycolipid

Homo sapiens

-

involved in elongation of oligosaccharide chains in glycolipids

638376, 638381

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

-

488980

-

-

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

-

638379

-

638379

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

-

638381

-

638381

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

substrate specificity

638376

-

638376

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

substrate specificity

638380

-

638380

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

hydrophobic substrates preferred

638376

-

638376

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

poor substrates are alpha-galactosides

638376

-

638376

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

R may be an oligosaccharide or a glycolipid

638376

-

638376

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Homo sapiens

-

p-nitrophenyl-beta-glycosides of galactose or lactose are by far the best substrates among oligosaccharides

638376

-

638376

?

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R

UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Notamacropus eugenii

-

-

638377

-

-

?

UDP-galactose + lactosylceramide

?

Homo sapiens

-

-

488980

-

-

?

UDP-galactose + lactosylceramide

?

Homo sapiens

-

best glycolipid substrate

638376

-

-

?

UDP-galactose + lactotriaosylceramide

UDP + lactotetraosylceramide

Homo sapiens

-

-

638379

-

638379

?

UDP-galactose + lactotriaosylceramide

UDP + lactotetraosylceramide

Homo sapiens

-

-

638381

-

638381

?

UDP-galactose + lactotriaosylceramide

UDP + lactotetraosylceramide

Homo sapiens

-

best substrate

638380

-

638380

?

UDP-galactose + methyl-beta-galactoside

UDP + beta-D-galactosyl-1,3-methyl-beta-galactoside

Homo sapiens

-

-

638376

-

-

?

UDP-galactose + methyl-beta-galactoside

UDP + beta-D-galactosyl-1,3-methyl-beta-galactoside

Notamacropus eugenii

-

-

638377

-

-

?

additional information

?

-

Homo sapiens

-

participates in the synthesis of glycosphingolipids

690818

-

-

?

additional information

?

-

Notamacropus eugenii

-

glucose is a very poor acceptor substrate

638377

-

-

?