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2.4.1.175: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.175

Reaction

UDP-N-acetyl-alpha-D-galactosamine
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
+
[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

AcbD, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, II, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin polymerase, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glycosyltransferase, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-2/chondroitin polymerizing factor, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase 1, chondroitin synthase-1, chondroitin synthase-2, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-2, ChSy-3, CHSY1, CpCS, Cpha266_2341, CS glycosyltransferase, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CS synthase-1, CSGalNAcT-2, CSGlcA-T, CSS1, CSS2, CSS3, GalNAc-T, glucuronyl-N-acetylgalactosaminylproteoglycan beta1,4-N-acetylgalactosaminyltransferase, K4CP, More, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferasec II

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

Disease

Disease on EC 2.4.1.175 - glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Brachydactyly
Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling.
Carcinogenesis
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells.
Choriocarcinoma
Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells.
Colorectal Neoplasms
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Neoplasm Metastasis
Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells.
Neoplasms
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NF?B and/or caspase-3/7 signaling pathway.
Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells.