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2.4.1.173: sterol 3beta-glucosyltransferase

This is an abbreviated version!
For detailed information about sterol 3beta-glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.173

Reaction

UDP-glucose
+
a sterol
=
UDP
+
a sterol 3-beta-D-glucoside

Synonyms

Atg26, AtSGT, autophagy-related protein 26, CG synthetase, pUGT51, ScAtg26, SGT, SGT1, SGT2, SGT3, SGT4, SGTL1, SgtL2, SgtL4, SlSGT1, SlSGT2, SlSGT3, SlSGT4, Solyc04g051150.2.1, Solyc04g071540.2.1, Solyc06g007980.2.1, Solyc09g061860.2.1, sterol glucosyltransferase, sterol glucosyltransferase Ugt51/Paz4, sterol glycosyltransferase, sterol-beta-D-glucosyltransferase, sterol:UDPG glucosyltransferase, UDP-Glc:sterol glucosyltransferase 80B1, UDP-glucose sterol glucosyltransferase, UDP-glucose sterol glycosyltransferase, UDP-glucose-sterol beta-glucosyltransferase, UDP-glucose-sterol glucosyltransferase, UDP-glucose:sterol glucosyltransferase, UDP-glycosyltransferase 51, UDPG-SGTase, UDPG:sterol glucosyltransferase, UDPglucose:sterol glucosyltransferase, Ugt51, Ugt51/Paz4, ugt51E1, UGT713B1, UGT80A2, UGT80B1, uridine diphosphoglucose-poriferasterol glucosyltransferase, uridine diphosphoglucose-sterol glucosyltransferase, USGT80B1

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.173 sterol 3beta-glucosyltransferase

Inhibitors

Inhibitors on EC 2.4.1.173 - sterol 3beta-glucosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Hydroxy-5-nitrobenzyl bromide
-
-
2-mercaptoethanol
slight inhibition of the isozyme
4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid
-
-
4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid
-
-
4-thio-UDP
-
50% of inhibition at 160 uM
5-Hg UDP
-
-
ATP
-
inhibition at 1-3 mM but slightly stimulation at low concentration
cetyltrimethylammonium bromide
-
strong inhibition
cholesteryl glucoside
-
-
coprostanol
diacylglycerol
-
with saturated fatty acids
diethyldicarbonate
-
protected against inactivation upon pre-incubation with stigmast-5-en-3beta-ol or UDP-glucose
epicholestanol
GDP-glucose
-
20% of inhibition at high concentration
GTP
-
the inhibitory effect of GTP is less prominent as compared to UDP
Hg2+
-
strongly inhibits the sterol glucosyltransferase activity, IC50 (mM): 0.5
iodoacetamide
-
strong and irreversible inhibition by thiol directed reagents like 4-chloromercuribenzoate, N-methylmaleimide and iodoacetamide suggest the requirement of free-SH groups for the catalytic activity
maleate buffer
-
strong inhibition at 50 mM
Mersalyl
-
50% of inhibition at 40 uM
monoacylglycerol
-
with saturated fatty acids
N-ethylmaleimide
n-octyl thioglucoside
-
irreversible inhibited, 50% of activity at 4.8 mM
NH4+
-
inhibited by
Ni2+
-
strongly inhibits the sterol glucosyltransferase activity, IC50 (mM): 1.2
p-chloromercuribenzenesulfonic acid
-
-
p-chloromercuribenzoate
p-mercuribenzenesulfonate
-
50% of irreversible inhibition at 0.5 mM, UDP and UDPG-glucose protect from inhibition of 10 mM
Phenylglyoxal
-
92% of inhibition at 10 mM
phosphate buffer
-
strong inhibition at 50 mM
-
pyridoxal 5'-phosphate
-
-
sodium deoxycholate
sodium taurocholate
triacylglycerol
-
with saturated fatty acids
Triton
strong inhibition of isozyme GhSGT1
Triton X-100
Tween 20
-
strong inhibition at concentrations below 0.05%
Tween 60
-
strong inhibition at concentrations below 0.05%
UDP-2',3'-dialdehyde
-
inhibits irreversibly the enzyme
UDP-mannose
-
50% of inhibition at 40 uM
additional information
-