2.4.1.170: isoflavone 7-O-glucosyltransferase
This is an abbreviated version!
For detailed information about isoflavone 7-O-glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.170
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2.4.1.170
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soybean
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isoflavonoids
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cotyledon
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daidzin
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kaempferol
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genistin
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2-hydroxyisoflavanone
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aglycones
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echinata
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glycyrrhiza
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ammonia-lyase
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phytoalexins
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long-distance
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luteolin
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flooding
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bradyrhizobium
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sojae
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pueraria
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cell-suspension
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phytophthora
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plant-microbe
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lobata
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enrei
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naringenin
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glycitin
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cicer
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glucosyltransferases
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arietinum
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drug development
- 2.4.1.170
- soybean
-
isoflavonoids
- cotyledon
- daidzin
- kaempferol
- genistin
- 2-hydroxyisoflavanone
-
aglycones
- echinata
-
glycyrrhiza
-
ammonia-lyase
-
phytoalexins
-
long-distance
- luteolin
-
flooding
-
bradyrhizobium
- sojae
-
pueraria
-
cell-suspension
-
phytophthora
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plant-microbe
- lobata
-
enrei
- naringenin
- glycitin
-
cicer
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glucosyltransferases
- arietinum
- drug development
Reaction
Synonyms
AtGT-2, F7GT, glucosyltransferase, uridine diphosphoglucose-isoflavone 7-O-, GmIF7GT, GmIF7GT1, GmUGT1, GmUGT3, GmUGT4, GmUGT7, GmUGT9, IF7GT, IFGT, isoflavone-7-O-glucosyltransferase, isoflavone-specific 7-O-glucosyltransferase, More, PlUGT1, UDP-glucose-flavonoid 7-O-glucosyltransferase, UDP-glucose: formononetin 7-O-glucosyltransferase, UDP-glucose:isoflavone 7-O-glucosyltransferase, UDPglucose-flavonoid 7-O-glucosyltransferase, UDPglucose:isoflavone 7-O-glucosyltransferase, UGT4, UGT709A4, UGT73F1, uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase
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Substrates Products
Substrates Products on EC 2.4.1.170 - isoflavone 7-O-glucosyltransferase
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REACTION DIAGRAM
UDP-alpha-D-glucose + isoliquiritigenin
UDP + isoliquiritigenin 7-O-beta-D-glucoside
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-
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?
UDP-glucose + an isoflavone
UDP + an isoflavone 7-O-beta-D-glucoside
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-
-
?
UDP-glucose + baicalein
UDP + baicalein 7-O-beta-D-glucoside
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very low activity
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-
?
UDP-glucose + eriodictyol
UDP + eriodictyol 7-O-beta-D-glucoside
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-
-
?
UDP-glucose + ferulic acid
UDP + 1-O-feruloyl-beta-D-glucose
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low activity
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-
?
UDP-glucose + liquiritigenin
UDP + liquiritigenin 7-O-beta-D-glucoside
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very low activity
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-
?
UDP-glucose + salicylic acid
UDP + salicylic acid 7-O-beta-D-glucoside
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very low activity
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-
?
UDP-glucose + scopoletin
UDP + scopoletin 7-O-beta-D-glucoside
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low activity
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-
?
UDP + biochanin A 7-O-beta-D-glucoside
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-
-
?
UDP + daidzein 7-O-beta-D-glucoside
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poor substrate
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-
?
UDP-glucose + daidzein
UDP + daidzein 7-O-beta-D-glucoside
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i.e. daidzin
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?
UDP-glucose + daidzein
UDP + daidzein 7-O-beta-D-glucoside
36% of the activity with genistein
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-
?
UDP-glucose + daidzein
UDP + daidzein 7-O-beta-D-glucoside
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-
i.e. daidzin
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?
UDP-glucose + daidzein
UDP + daidzein 7-O-beta-D-glucoside
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high activity
i.e. daidzin
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?
UDP-glucose + formononetin
UDP + formononetin 7-O-beta-D-glucoside
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best substrate
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-
?
UDP-glucose + formononetin
UDP + formononetin 7-O-beta-D-glucoside
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-
i.e. ononin
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?
UDP + genistein 7-O-beta-D-glucoside
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poor substrate
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-
?
UDP-glucose + genistein
UDP + genistein 7-O-beta-D-glucoside
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-
-
?
UDP-glucose + genistein
UDP + genistein 7-O-beta-D-glucoside
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i.e. genistin
-
?
UDP-glucose + genistein
UDP + genistein 7-O-beta-D-glucoside
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-
i.e. genistin
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?
UDP-glucose + genistein
UDP + genistein 7-O-beta-D-glucoside
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best substrate
i.e. genistin
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?
UDP + kaempferol 7-O-beta-D-glucoside
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-
-
?
UDP-glucose + naringenin
UDP + naringenin 7-O-beta-D-glucoside
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low activity
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-
?
UDP + quercetin 7-O-beta-D-glucoside
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-
-
?
?
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caffeic acid and esculetin do not react with the enzyme. AtGT-2 prefers flavonene to flavone or flavonol, both of which contain a double bond in the C ring. The relative conversion rate is 100% for eriodictyol, 71.6% for naringenin, 29.6% for apigenin, 92.1% for luteolin, 78.9% for kaempferol and 64.1% for quercetin.
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?
additional information
?
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caffeic acid and esculetin do not react with the enzyme. AtGT-2 prefers flavonene to flavone or flavonol, both of which contain a double bond in the C ring. The relative conversion rate is 100% for eriodictyol, 71.6% for naringenin, 29.6% for apigenin, 92.1% for luteolin, 78.9% for kaempferol and 64.1% for quercetin.
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?
additional information
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none of the following phenolics serve as glucosyl acceptors: cyanidin, trans-p-coumaric acid, caffeic acid, benzoic acid, m- and p-hydroybenzoic acid, salicylic acid, salicyl alcohol and hydroquinone.
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?
additional information
?
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the relative activites for UDP-glucuronic acid and for UDP-galactose is 0% and for UDP-glucose 12%, all tested with genistein as glycosyl acceptor
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additional information
?
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GmUGT1 is active with UDP-galactose and UDP-glucuronic acid as substrates. It displays high specific activities toward isoflavones (genistein and daidzein) to produce their 7-O-beta-D-glucosides, it also shows considerable levels of activities toward other flavonoids such as kaempferol, quercetin, naringenin and apigenin. GmUGT1 is also capable of acting on the flavone luteolin, (S)-equol, a 4',7-isoflavandiol, and (R)-equol
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?
additional information
?
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GmUGT1 is active with UDP-galactose and UDP-glucuronic acid as substrates. It displays high specific activities toward isoflavones (genistein and daidzein) to produce their 7-O-beta-D-glucosides, it also shows considerable levels of activities toward other flavonoids such as kaempferol, quercetin, naringenin and apigenin. GmUGT1 is also capable of acting on the flavone luteolin, (S)-equol, a 4',7-isoflavandiol, and (R)-equol
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?
additional information
?
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in contrast to GmUGT1, UDP-galactose and UDP-glucuronic acid are essentially inert as substrates for GmUGT3, glucosyl-acceptor substrate specificity, overview. No activity with kaempferol, quercetin, naringenin, apigenin, and luteolin
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?
additional information
?
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in contrast to GmUGT1, UDP-galactose and UDP-glucuronic acid are essentially inert as substrates for GmUGT3, glucosyl-acceptor substrate specificity, overview. No activity with kaempferol, quercetin, naringenin, apigenin, and luteolin
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?
additional information
?
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in contrast to GmUGT1, UDP-galactose and UDP-glucuronic acid are essentially inert as substrates for GmUGT4, glucosyl-acceptor substrate specificity, overview. No activity with kaempferol, quercetin, naringenin, apigenin, and luteolin
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?
additional information
?
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in contrast to GmUGT1, UDP-galactose and UDP-glucuronic acid are essentially inert as substrates for GmUGT4, glucosyl-acceptor substrate specificity, overview. No activity with kaempferol, quercetin, naringenin, apigenin, and luteolin
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?
additional information
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the enzyme might play a role in defense against external stresses such as UV radiation and pathogen attack
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additional information
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substrate specificity, the flavonoids kaempferol, apigenin, and quercetin are poor substrates
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?
additional information
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no activity with apigenin, kaempferol, luteolin, naringenin, and quercetin
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?
additional information
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no activity with apigenin, kaempferol, luteolin, naringenin, and quercetin
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?
additional information
?
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the enzyme is relatively specific for isoflavone aglycones, while flavonoid substrates are poorly accepted. No activity with cyanidin, luteolin, kaempferol, and quercetin, naringenin and apigenin are poor substrates, substrate specificity, overview
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?