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2.4.1.170: isoflavone 7-O-glucosyltransferase

This is an abbreviated version!
For detailed information about isoflavone 7-O-glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.170

Reaction

UDP-glucose
+
an isoflavone
=
UDP
+
an isoflavone 7-O-beta-D-glucoside

Synonyms

AtGT-2, F7GT, glucosyltransferase, uridine diphosphoglucose-isoflavone 7-O-, GmIF7GT, GmIF7GT1, GmUGT1, GmUGT3, GmUGT4, GmUGT7, GmUGT9, IF7GT, IFGT, isoflavone-7-O-glucosyltransferase, isoflavone-specific 7-O-glucosyltransferase, More, PlUGT1, UDP-glucose-flavonoid 7-O-glucosyltransferase, UDP-glucose: formononetin 7-O-glucosyltransferase, UDP-glucose:isoflavone 7-O-glucosyltransferase, UDPglucose-flavonoid 7-O-glucosyltransferase, UDPglucose:isoflavone 7-O-glucosyltransferase, UGT4, UGT709A4, UGT73F1, uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.170 isoflavone 7-O-glucosyltransferase

Application

Application on EC 2.4.1.170 - isoflavone 7-O-glucosyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
isoflavonoids and their glycosides may prove useful as anticancer drugs with added advantage of increased solubility, stability and bioavailability. Among the six compounds tested, genistein most effectively inhibits the growth of B16F10 and AGS cells, with IC50 values of 0.0077 mM and 0.0398 mM, respectively. Unlike derivatives of genistein (genistin and biochanin A), the glycosylated and methylated forms of daidzein (daidzin and formononetin) exhibit more effective growth inhibition than aglycon, daidzein