2.4.1.16: chitin synthase

This is an abbreviated version!
For detailed information about chitin synthase, go to the full flat file.

Reaction

Synonyms

AaCHS-1, acetylglucosaminyltransferase, chitin-uridine diphosphate, AgCHS-1, AgCHS-2, Ar-CS1, BcChsVI, BmCHSA-2a, BmCHSA-2b, CaChs1, CaChs2p, chitin synthase 1, chitin synthase 2, chitin synthase 3, chitin synthase 3a, chitin synthase 4, chitin synthase 5, chitin synthase 6, chitin synthase 7, chitin synthase A, chitin synthase B, chitin synthase II, chitin synthase III, chitin synthase protein 2, chitin synthetase, chitin synthetase I, chitin synthetase II, chitin synthetase III, chitin-UDP acetyl-glucosaminyl transferase 1, chitin-UDP acetyl-glucosaminyl transferase 2, chitin-UDP acetyl-glucosaminyl transferase 3, chitin-UDP acetyl-glucosaminyl transferase 4, chitin-UDP acetyl-glucosaminyl transferase 5, chitin-UDP acetyl-glucosaminyl transferase 6, chitin-UDP acetyl-glucosaminyl transferase 7, chitin-UDP N-acetylglucosaminyltransferase, chitin-uridine diphosphate acetylglucosaminyltransferase, CHS, CHS B, chs-1, chs-2, CHS-3, CHS-6, Chs1, CHS1a, CHS1b, CHS1p, Chs2, CHS2p, CHS3, CHS3a, Chs3p, CHS4, Chs4p, CHS5, CHS6, CHS7, Chs8, chsA, chsB, chsC, chsE, CHSI, CHSIIIa, CHSIIIb, class A chitin synthase, class I CHS, class IV CaChs3p, class IV chitin synthase, class IV CHS, class V chitin synthase, class Vb chitin synthase, class VII chitin synthase, class-A CHS, class-B CHS, class-II chitin synthase 1, CSI, CSII, CSIII, CsmA, CsmB, DmCHS-1, DmCHS-2, DmeChSB, EhCHS-1, EhCHS-2, LcCHS-1, LeChs1, LsCHS-1, Mcs1, More, MsCHS-1, MsCHS1, MsCHS2, myosin motor-like chitin synthase, Ov-chs-2, PdChsVII, TcCHS1, TcCHS2, trans-N-acetylglucosaminosylase, UDP-GlcNAc:chitin 4-alpha-N-acetylglucosaminyltransferase, UmCHS3, UmCHS6, WdCHS1, WdChs3p, WdChs5p

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.16 chitin synthase

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Results	in table
56	Activating Compound
15375	AA Sequence
7	Application
1	CAS Registry Number
55	Cloned(Commentary)
15	Expression
65	General Information
7	General Stability
53	IC50 Value
307	Inhibitors
31	Ki Value [mM]
29	KM Value [mM]
108	Localization
67	Metals/Ions
37	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
289	Organism
3	Pathway
20	PDB ID
29	pH Optimum
4	pH Range
18	pI Value
34	Posttranslational Modification
46	Protein Variants
16	Purification (Commentary)
2	Reaction
1	Reaction Type
241	Reference
191	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
174	Substrates and Products (Substrate)
32	Subunits
247	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
7	Temperature Range [°C]
9	Temperature Stability [°C]

General Stability

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General Stability on EC 2.4.1.16 - chitin synthase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

dithithreitol is required to prevent melanization of the enzyme extract

Anopheles gambiae

-

736241

enzyme is very sensitive to proteolytic degradation

Exophiala dermatitidis

Q8TGV2

706474

high sensitivity of chitosomal chitin synthase 2 to high centrifugal forces

Saccharomyces cerevisiae

-

488668

the zymogen is highly stable

Amylomyces rouxii

-

488661

treatment with digitonin causes an increase in specific activity and stability

Coprinopsis cinerea

-

488650

upon lyophilization, about 70% of the activity is recovered

Saccharomyces cerevisiae

-

488659

wild-type isozyme Chs2 has a half-life of 25 min

Saccharomyces cerevisiae

-

685019