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2.4.1.155: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.155

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
=
UDP
+
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-mannoside beta1-6-UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase, alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, beta N-acetylglucosaminyltransferase V, beta-1,6-N-acetylglucosaminyltransferase V, beta1, 6-N-acetylglucosaminyltransferase V, beta1,6-N-acetylglucosaminyltransferase, beta1,6-N-acetylglucosaminyltransferase V, beta1,6-N-acetylglucosaminyltransferase-V, Glc-NAcT-V, GlcNAcT-V, GlcNAcTase-V, glycosyltransferase, GnT-IV, GnT-IX, GnT-V, GnT-Va, GnT-VB, Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase V, Golgi UCD-GlcNAc:N-acetylglucosaminyltransferase 5, mannoside acetylglucosaminyltransferase 5, Mgat5, N-acetylglucosaminyltransferase V, N-acetylglucosaminyltransferase Va, N-acetylglucosaminyltransferase-V, N-acetylglucosaminyltransferase-Va, N-acetylglucosaminyltransferase-Vb, N-acetylglucsaminyltransferase V, UDP-N-acetylglucosamine:a-mannoside beta-1,6-N-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

Inhibitors

Inhibitors on EC 2.4.1.155 - alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ADP-N-acetylglucosamine
-
20 mM
antisense GnT-V
-
-
-
Ba2+
-
30% of maximal activity
beta1,4-N-acetylglucosaminyltransferase-III
-
competitive inhibitor
-
beta1,6-N-acetylglucosaminyltransferase III
-
GnT-III, competitive inhibitor
-
Ca2+
-
20% of maximal activity; 35% of maximal activity
CDP-N-acetylglucosamine
-
20 mM
Cu2+
-
30% of maximal activity
EDTA
-
10% of maximal activity in absence of any cation and in presence in EDTA
Fe2+
-
15% of maximal activity
Fe3+
-
1 mM inhibits
GDP-N-acetylglucosamine
-
20 mM
Mg2+
-
50% of maximal activity
N-Acetyl-D-glucosaminyl-1,2-alpha-4-O-methyl-mannosyl-1,6-beta-D-glucosyl-O-(CH2)7-CH3
-
-
N-Acetyl-D-glucosaminyl-1,2-alpha-6-deoxy-mannosyl-1,6-beta-D-glucosyl-O-(CH2)7-CH3
N-Acetyl-D-glucosaminyl-1,2-alpha-6-deoxy-mannosyl-1,6-beta-D-glucosyl-O-(CH2)8-COOCH3
-
-
N-bromosuccinimide
-
1 mM inhibits
NaCl
-
more than 0.2 M, decrease in enzyme acitivty; more than 50 mM, decrease in enzyme acitivty
Ni2+
-
15% of maximal activity
PC-MGAT5si
-
a MGAT5 knock-down vector is used for animal studies in mice
-
siRNA
-
TDP-N-acetylglucosamine
-
20 mM
Zn2+
-
10% of maximal activity
additional information
-