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2.4.1.155: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.155

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
=
UDP
 +
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-mannoside beta1-6-UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase, alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, beta N-acetylglucosaminyltransferase V, beta-1,6-N-acetylglucosaminyltransferase V, beta1, 6-N-acetylglucosaminyltransferase V, beta1,6-N-acetylglucosaminyltransferase, beta1,6-N-acetylglucosaminyltransferase V, beta1,6-N-acetylglucosaminyltransferase-V, Glc-NAcT-V, GlcNAcT-V, GlcNAcTase-V, glycosyltransferase, GnT-IV, GnT-IX, GnT-V, GnT-Va, GnT-VB, Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase V, Golgi UCD-GlcNAc:N-acetylglucosaminyltransferase 5, mannoside acetylglucosaminyltransferase 5, Mgat5, N-acetylglucosaminyltransferase V, N-acetylglucosaminyltransferase Va, N-acetylglucosaminyltransferase-V, N-acetylglucosaminyltransferase-Va, N-acetylglucosaminyltransferase-Vb, N-acetylglucsaminyltransferase V, UDP-N-acetylglucosamine:a-mannoside beta-1,6-N-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

Expression

Expression on EC 2.4.1.155 - alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
chitosan oligosaccharides (COS) inhibit the protein expression of GnT-V in a dose dependent manner
decreased expression after exogenous addition alltrans-retinoic acid
-
during interferon-gamma-induced inflammation, the level of GnT-V in THP-1 monocytes are significantly decreased
-
high GnT-V expression correlated with FIGO surgical stage, strong immunostaining in mucinous adendocarcinoma
-
increased expression after anti-CD3 stimulation
-
overexpressed in malignant tumors
-
selective knockdown of GnT-Va expression, inhibition of ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis
-
the expression of GnT-V is quite low in normal liver tissue but is increased under conditions of chronic hepatitis and liver regeneration
-
the PI3K/Akt signaling pathway is involved in regulation of GnT-V expression