2.4.1.148: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase This is an abbreviated version! For detailed information about acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file .
Reaction
UDP-N-acetyl-D-glucosamine +
N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R =
UDP +
N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R
Synonyms acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-, B, bC2GnT-M, C2GnT, C2GnT-2, C2GnT-I, C2GnT-L, c2GnT-M, C2GnT1, C2GnT2, C2GnT3, core 2 beta 1,6 N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase-M, core 2 beta1,6-N-acetylglucosaminyltransferase, core 2 beta6 GlcNAc-transferase, core 2 N-acetylglucosaminyltransferase-M, core 2 _1,6 N-acetylglucosaminyltransferase mucus-type, core 4 beta6-GalNAc-transferase, core 6beta-GalNAc-transferase B, leukocyte-type core 2 beta1,6-N-acetylglucosaminyltransferase, More, mucin-type core 2 beta-1,6-N-acetylglucosaminyltransferase-M, mucin-type core 2 beta-6-GlcNAc-transferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-acetylglucosaminyltransferase B
ECTree
Source Tissue
Source Tissue on EC 2.4.1.148 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
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isoform C2GnT2 is highly expressed mainly in the stomach and the colon
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airway epithelial cell line
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isoform C2GnT3 is highly expressed mainly in the small intestine, liver and spleen
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airway epithelial cell line
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enzyme activity is regulated during estrous cycle, overview
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the enzyme forms complexes with NMIIA in Panc1-bC2GnT-M (c-Myc) cells
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isoform C2GnT3 is highly expressed mainly in the small intestine, liver and spleen
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high activity
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isoform C2GnT3 is highly expressed mainly in the small intestine, liver and spleen
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isoform C2GnT2 is highly expressed mainly in the stomach and the colon
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additional information
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isoform C2GnT1 is widely expressed in most tissues
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not in liver
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not in submaxillary glands
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