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2.4.1.147: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.147

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
=
UDP
 +
O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-3)-, B3GNT6, beta3-N-acetylglucosaminyltransferase-6, beta3Gn-T6, beta3GnT-6, C3 beta3GnT6, C3GnT, core 3 beta 1,3-N-acetylglucosaminyltransferase, core 3 beta1,3-N-acetylglucosaminyltransferase, core 3 beta3-GlcNAc-T, core 3 beta3-N-acetylglucosaminyltransferase 6, core 3 synthase, core 3beta-GlcNAc-transferase, core3 O-glycan synthase, core3 synthase, mucin core 3 beta3-GlcNAc-transferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, UDPGlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, uridine diphosphate, uridine diphosphoacetylglucosamine-mucin beta(1-3)-acetylglucosaminyltransferase, [UDP]-GlcNAc:betaGal beta1,3-N-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

Disease

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Disease on EC 2.4.1.147 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas.
Adenoma
Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Adenomatous Polyposis Coli
Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.
alpha-Thalassemia
The influence of uridine diphosphate glucuronosyl transferase 1A promoter polymorphisms, beta-globin gene haplotype, co-inherited alpha-thalassemia trait and Hb F on steady-state serum bilirubin levels in sickle cell anemia.
Anemia
The influence of uridine diphosphate glucuronosyl transferase 1A promoter polymorphisms, beta-globin gene haplotype, co-inherited alpha-thalassemia trait and Hb F on steady-state serum bilirubin levels in sickle cell anemia.
Uridine diphosphate glucuronosyl transferase 1A (UGT1A1) promoter polymorphism in young patients with sickle cell anaemia: report of the first cohort study from Nigeria.
Anemia, Sickle Cell
The influence of uridine diphosphate glucuronosyl transferase 1A promoter polymorphisms, beta-globin gene haplotype, co-inherited alpha-thalassemia trait and Hb F on steady-state serum bilirubin levels in sickle cell anemia.
The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease.
Uridine diphosphate glucuronosyl transferase 1A (UGT1A1) promoter polymorphism in young patients with sickle cell anaemia: report of the first cohort study from Nigeria.
Arthritis, Rheumatoid
Uridine Diphosphate Promotes Rheumatoid Arthritis Through P2Y6 Activation.
Breast Neoplasms
Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation.
Carcinogenesis
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues.
Carcinoma
Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.
Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex.
Expression of alpha-gal epitopes on ovarian carcinoma membranes to be used as a novel autologous tumor vaccine.
Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.
Phosphate metabolites and steroid hormone receptors of benign and malignant breast tumors. A Nuclear Magnetic Resonance study.
[Core 3 synthase is down-regulated in colon carcinoma and suppresses the cancer metastasis]
Carcinoma, Ehrlich Tumor
Uridine diphosphate reductase of Ehrlich ascites tumor is insensitive to hydroxyurea.
Carcinoma, Hepatocellular
Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2.
Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient.
Carcinoma, Non-Small-Cell Lung
Weekly regimen of irinotecan/docetaxel in previously treated non-small cell lung cancer patients and correlation with uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism.
Carcinoma, Small Cell
Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.
Cholangiocarcinoma
Association between the expression of core 3 synthase and survival outcomes of patients with cholangiocarcinoma.
Choledocholithiasis
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism is associated with choledocholithiasis in Taiwanese patients.
Colonic Neoplasms
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Colorectal Neoplasms
Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan.
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
FOLFIRI Combined with Bevacizumab as First-Line Treatment for Metastatic Colorectal Cancer Patients with Hyperbilirubinemia after UGT1A1 Genotyping.
Pharmacogenomics in colorectal carcinomas: future perspectives in personalized therapy.
Prospective Phase II Study of FOLFIRI for mCRC in Japan, Including the Analysis of UGT1A1*28/*6 Polymorphisms.
The Correlation Between UGT1A1 Gene Phenotypes and the Clinical Prognosis of Advanced Colorectal Cancer After FOLFIRI Therapy.
UGT1A1 gene polymorphism is associated with toxicity and clinical efficacy of irinotecan-based chemotherapy in patients with advanced colorectal cancer.
UGT1A1 gene polymorphism: impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer.
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Congenital Disorders of Glycosylation
A case of early onset epileptic encephalopathy with de novo mutation in SLC35A2: Clinical features and treatment for epilepsy.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
A case of early onset epileptic encephalopathy with de novo mutation in SLC35A2: Clinical features and treatment for epilepsy.
Crigler-Najjar Syndrome
AAV8 Gene Therapy Rescues the Newborn Phenotype of a Mouse Model of Crigler-Najjar.
Determining the Minimally Effective Dose of a Clinical Candidate AAV Vector in a Mouse Model of Crigler-Najjar Syndrome.
Transplanted Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Support Liver Regeneration in Gunn Rats.
Type I crigler najjar syndrome in Tunisia: a study of 30 cases.
[Anesthetic and postoperative care of a patient with Crigler-Najjar syndrome type II]
Dehydration
ABA UDP-glucosyltransferases play a crucial role in ABA homeostasis in Arabidopsis.
Drug-Related Side Effects and Adverse Reactions
Genome-based biomarkers for adverse drug effects, patient enrichment and prediction of drug response, and their incorporation into clinical trial design.
Prediction By Pharmacogenetics Of Safety And Efficacy Of Non-Steroidal Anti-Inflammatory Drugs: A Review.
Dry Eye Syndromes
Proteomics Differentiate Between Thyroid-Associated Orbitopathy and Dry Eye Syndrome.
Epilepsy
The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients.
Fanconi Syndrome
Two familial cases of high blood galactose of unknown aetiology.
galactokinase deficiency
Cataract and metabolic disease.
Galactosemias
An interference-free two-step enzyme assay with UPLC-tandem mass spectrometric product measurement for the clinical diagnosis of uridine diphosphate galactose-4-epimerase deficiency.
Cataract and metabolic disease.
Estimates of uridine diphosphate hexoses in erythrocytes: implications for galactosemia.
Formation of galactose-1-phosphate from uridine diphosphate galactose in erythrocytes from patients with galactosemia.
Galactosemia caused by generalized uridine diphosphate galactose-4-epimerase deficiency.
Galactosemia in Thai patient at Phramongkutklao Hospital: a case report.
Galactosemia: the uridine diphosphate galactose deficiency-uridine treatment controversy.
Galactosemia: when is it a newborn screening emergency?
GALT Deficiency Galactosemia.
HPLC analysis of uridine diphosphate sugars: decreased concentrations of uridine diphosphate galactose in erythrocytes and cultured skin fibroblasts from classical galactosemia patients.
Measurements of uridine diphosphate glucose and uridine diphosphate galactose--an appraisal.
Measurements of uridine diphosphate hexoses in galactosemia.
Modulation of rat tissue galactose-1-phosphate uridyltransferase by uridine and uridine triphosphate.
Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model.
Pathophysiology and targets for treatment in hereditary galactosemia: A systematic review of animal and cellular models.
Uridine diphosphate glucose and uridine diphosphate galactose in galactosemia.
Uridine diphosphate hexoses in leukocytes and fibroblasts of classic galactosemics and patients with other metabolic diseases.
Gallstones
Gilbert's syndrome accounts for the phenotypic variability of congenital dyserythropoietic anemia type II (CDA-II).
The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease.
UGT1A1 variation and gallstone formation in sickle cell disease.
Gaucher Disease
Gaucher disease: clinical profile and therapeutic developments.
Substrate reduction therapy for lysosomal storage diseases.
Genetic Diseases, Inborn
Origin and spread of a common deletion causing mucolipidosis type II: insights from patterns of haplotypic diversity.
Gilbert Disease
Donor liver uridine diphosphate (UDP)-glucuronosyltransferase-1A1 deficiency causing Gilbert's syndrome in liver transplant recipients.
Gilbert's Syndrome With Diabetes Mellitus.
Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia.
TATA-Box polymorphism in the uridine diphosphate glucuronosyl transferase gene in Portuguese patients with clinical diagnosis of Gilbert Syndrome.
Two cases of constitutional unconjugated hyperbilirubinemia with marked retention of indocyanine green.
UGT1A1 variation and gallstone formation in sickle cell disease.
Glioma
Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy.
Hepatitis
Enzymatic studies of glucuronide formation in impaired liver. IV. Liver glucuronyl transferase activity and uridine diphosphate glucuronic acid content in viral hepatitis patients.
Uridine diphosphate glucoronosyl transferases, candidate antigens of liver-kidney microsomal antibodies in hepatitis delta virus-infected patients.
[Uridine diphosphate glucose in acute viral hepatitis]
Hepatitis B, Chronic
Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation.
Hepatitis D, Chronic
Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D.
Hyperbilirubinemia, Neonatal
211 G to A Variation of UDP-Glucuronosyl Transferase 1A1 Gene and Neonatal Breastfeeding Jaundice.
Association of UGT1A1 variants and hyperbilirubinemia in breast-fed full-term Chinese infants.
Effects of Gly71Arg mutation in UGT1A1 gene on neonatal hyperbilirubinemia: a systematic review and meta-analysis.
Hyperglycemia
Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system.
Immunoglobulin G4-Related Disease
UPLC-MS based plasma metabolomics and lipidomics reveal alterations associated with IgG4-related disease.
Infections
Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1?-XBP1s arm of the unfolded protein response.
Inflammatory Bowel Diseases
Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate.
l-iditol 2-dehydrogenase deficiency
Cataract and metabolic disease.
Leukemia
Reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity.
Lung Neoplasms
Uridine diphosphate glucuronide transferase 1A1FNx0128 gene polymorphism and the toxicity of irinotecan in recurrent and refractory small cell lung cancer.
Weekly regimen of irinotecan/docetaxel in previously treated non-small cell lung cancer patients and correlation with uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism.
Mastocytoma
Biosynthesis of heparin. Solubilization and partial purification of uridine diphosphate glucuronic acid: acceptor glucuronosyltransferase from mouse mastocytoma.
Meningioma
[Uridine diphosphate sugar in meningiomas of the brain]
Metabolic Diseases
Uridine diphosphate hexoses in leukocytes and fibroblasts of classic galactosemics and patients with other metabolic diseases.
Mucolipidoses
A novel splice site mutation in the GNPTAB gene in an Iranian patient with mucolipidosis II ?/?.
Identification and characterization of 30 novel pathogenic variations in 69 unrelated Indian patients with Mucolipidosis Type II and Type III.
Molecular analysis of the GNPTAB and GNPTG genes in 13 patients with mucolipidosis type II or type III - identification of eight novel mutations.
Mucolipidosis II (I-Cell Disease) and Mucolipidosis IIIA (Classical Pseudo-Hurler Polydystrophy) Are Caused by Mutations in the GlcNAc-Phosphotransferase alpha / beta -Subunits Precursor Gene.
Origin and spread of a common deletion causing mucolipidosis type II: insights from patterns of haplotypic diversity.
Muscular Diseases
Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy.
Myocardial Infarction
Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.
Neoplasm Metastasis
Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation.
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex.
Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis.
[Core 3 synthase is down-regulated in colon carcinoma and suppresses the cancer metastasis]
Neoplasms
An integrative framework identifies alternative splicing events in colorectal cancer development.
Antiadhesive Nanosomes Facilitate Targeting of the Lysosomal GlcNAc Salvage Pathway through Derailed Cancer Endocytosis.
Core3 glycan as tumor suppressor.
Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex.
Enzymic synthesis of uridine diphosphate glucosamine and heparin from [14C]glucosamine by a mouse mast-cell tumor.
Expression of alpha-gal epitopes on ovarian carcinoma membranes to be used as a novel autologous tumor vaccine.
Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis.
Expression of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase isozymes T1 and T2 in human colorectal cancer.
Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas.
Pharmacogenetics and cancer chemotherapy.
SYSTEM OF URIDINE DIPHOSPHATE GLUCOSE AND OF GLYCOGEN TRANSFORMATION IN ASCITES CANCER CELLS.
The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy.
The synthesis of uridine diphosphate xylose by particulate preparations from mouse mast-cell tumors.
UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.
Uridine diphosphate reductase of Ehrlich ascites tumor is insensitive to hydroxyurea.
[Core 3 synthase is down-regulated in colon carcinoma and suppresses the cancer metastasis]
[Effect of irradiation with fast electrons on the uridine diphosphate glucose mechanism of glycogen synthesis in NKly tumors, spleen and liver of tumor bearing mice]
[THE URIDINE DIPHOSPHATE GLUCOSE SYSTEM AND GLYCOGEN TRANSFORMATION IN ASCITES TUMOR CELLS.]
Neutropenia
Associations between UGT1A1*6 or UGT1A1*6/*28 polymorphisms and irinotecan-induced neutropenia in Asian cancer patients.
UGT1A1 Gene Polymorphisms and the Toxicities of FOLFIRI in Chinese Han Patients with Gastrointestinal Cancer.
Pancreatic Neoplasms
Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis.
Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer.
Pneumonia
The purinergic g protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation.
Prostatic Hyperplasia
Activation of P2Y6 Receptors Facilitates Nonneuronal Adenosine Triphosphate and Acetylcholine Release from Urothelium with the Lamina Propria of Men with Bladder Outlet Obstruction.
Prostatic Neoplasms
Core3 glycan as tumor suppressor.
Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex.
Moiety modeling framework for deriving moiety abundances from mass spectrometry measured isotopologues.
UDP-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer.
Pruritus
The relationship between dermatological findings and serum interleukin 31 and serum uridine diphosphate glucose ceramide glucosyltransferase levels among patients with chronic kidney disease.
Renal Insufficiency, Chronic
The relationship between dermatological findings and serum interleukin 31 and serum uridine diphosphate glucose ceramide glucosyltransferase levels among patients with chronic kidney disease.
Sandhoff Disease
Enhancement by Uridine Diphosphate of Macrophage Inflammatory Protein-1 Alpha Production in Microglia Derived from Sandhoff Disease Model Mice.
Small Cell Lung Carcinoma
Uridine diphosphate glucuronide transferase 1A1FNx0128 gene polymorphism and the toxicity of irinotecan in recurrent and refractory small cell lung cancer.
Stomach Neoplasms
Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIRI.
Trypanosomiasis, African
Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness.
Tuberculosis
Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis.
udp-glucose 4-epimerase deficiency
Uridine diphosphate galactose 4-epimerase deficiency.