2.4.1.145: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

(GnT)-IVa, (GnT)-IVb, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, alpha1,3-mannosyl-beta1,4-N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, EC 2.4.1.51, GlcNAcTase-IV, GnT IV, GnT-IV, GnT-IVa, GnT-IVb, GnTIVa, Mgat4a, Mgat4b, N-acetylglucosaminyltransferase IV, N-acetylglucosaminyltransferase IVa, N-acetylglucosaminyltransferase-IV, N-acetylglucosaminyltransferase-IVa, N-acetylglucosaminyltransferase-IVb, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.145 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

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Results	in table
1	Activating Compound
47	AA Sequence
3	Application
1	CAS Registry Number
8	Cloned(Commentary)
63	Disease/ Diagnostics
2	Expression
8	General Information
5	Inhibitors
14	KM Value [mM]
2	Localization
5	Metals/Ions
4	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
26	Organism
4	Pathway
2	PDB ID
3	pH Optimum
2	pH Range
2	Posttranslational Modification
2	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
24	Reference
63	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
29	Substrates and Products (Substrate)
1	Subunits
42	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.145 - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]

UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[lysosome-associated membrane glycoprotein 2]

Homo sapiens

Q9UM21

i.e. LAMP-2, LAMP-2 has 16 N-glycans which play crucial roles in cell adhesion to ECM and metastasis of cancer cells because N-glycans configure cell surface ligands of cancer cells for galectin-1, galectin-3, and selectins on extracellular matrix or the membranes of the counter cell

759880

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Homo sapiens

Q9UM21

-

759880

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

4 entries

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Gallus gallus

-

-

637306

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Homo sapiens

-

GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans

673896

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Homo sapiens

-

GnT-IVb might contribute to the basal GnT-IV activity in cells

673896

-

-

?

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

Homo sapiens

-

the enzyme is involved in the branch formation of Asn-linked sugar chains

658123

-

-

?