2.4.1.144: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.144
-
2.4.1.144
-
bisect
-
n-glycans
-
glycosyltransferases
-
n-acetylglucosamine
-
fucosyltransferase
-
gnt-iv
-
beta-linked
-
xenoantigens
-
tetraantennary
-
e4-pha
-
medicine
-
alpha-galactosylation
-
antennary
-
glcnac-tiii
-
trimannosyl
-
erythroagglutinating
-
alpha-gal
-
diagnostics
-
synthesis
- 2.4.1.144
-
bisect
- n-glycans
- glycosyltransferases
- n-acetylglucosamine
-
fucosyltransferase
- gnt-iv
-
beta-linked
-
xenoantigens
-
tetraantennary
-
e4-pha
- medicine
-
alpha-galactosylation
-
antennary
-
glcnac-tiii
-
trimannosyl
-
erythroagglutinating
- alpha-gal
- diagnostics
- synthesis
Reaction
Synonyms
(GnT)-III, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycopeptide beta4-, III, beta(1,4)-N-acetylglucosaminyltransferase III, beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-N-acetylglucosaminyltransferase III, beta-D-mannoside beta-1,4-N-acetylglucosaminyltransferase, beta1,4-N-acetylglucosaminyltransferase III, EC 2.4.1.51, GlcNAc-transferase-III, GlcNAcTase-III, GnT-III, GnTIII, Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase III, MGAT3, N-acetyl-glucosaminyltransferase III, N-acetylglucosaminyltransferase III, N-acetylglucosaminyltransferase-III, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, uridine diphosphate (UDP)-N-acetylglucosamin/beta-D-mannoside beta-1,4-N-acetylglucosaminyltransferase III, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
ECTree
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Reference on EC 2.4.1.144 - beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schachter, H.; Brockhausen, I.; Hull, E.
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis
Methods Enzymol.
179
351-397
1989
Gallus gallus, Cricetulus griseus, Homo sapiens, Rattus norvegicus
Taniguchi, N.; Nishikawa, A.; Fujii, S.; Gu, J.
Glycosyltransferase assays using pyridylaminated acceptors: N-acetylglucosaminyltransferase III, IV, and V
Methods Enzymol.
179
397-408
1989
Rattus norvegicus
Narasimhan, S.
Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides
J. Biol. Chem.
257
10235-10242
1982
Gallus gallus
Nishikawa, A.; Ihara, Y.; Hatakeyama, M.; Kangawa, K.; Taniguchi, N.
Purification, cDNA cloning, and expression of UDP-N-acetylglucosamine: beta-D-mannoside beta-1,4N-acetylglucosaminyltransferase III from rat kidney
J. Biol. Chem.
267
18199-18204
1992
Cricetulus griseus, Homo sapiens, Rattus norvegicus (Q02527)
Miyoshi, E.; Nishikawa, A.; Ihara, Y.; Hayashi, N.; Fusamoto, H.; Kamada, T.; Taniguchi, N.
Selective suppression of N-acetylglucosaminyltransferase III activity in a human hepatoblastoma cell line transfected with hepatitis B virus
Cancer Res.
54
1854-1858
1994
Homo sapiens
Yoshimura, M.; Nishikawa, A.; Ihara, Y.; Nishiura, T.; Nakao, H.; Kanayama, Y.; Matuzawa, Y.; Taniguchi, N.
High expression of UDP-N-acetylglucosamine:beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in chronic myelogenous leukemia in blast crisis
Int. J. Cancer
60
443-449
1995
Homo sapiens
Nagai, K.; Ihara, Y.; Wada, Y.; Taniguchi, N.
N-Glycosylation is requisite for the enzyme activity and Golgi retention of N-acetylglucosaminyltransferase III
Glycobiology
7
769-776
1997
Rattus norvegicus
Taniguchi, N.; Yoshimura, M.; Miyoshi, E.; Ihara, Y.; Nishikawa, A.; Kang, R.; Ikeda, Y.
Gene expression and regulation of N-acetylglucosaminyltransferases III and V in cancer tissues
Adv. Enzyme Regul.
38
223-232
1998
Homo sapiens, no activity in Mus musculus
Rudd, P.M.; Endo, T.; Colominas, C.; Groth, D.; Wheeler, S.F.; Harvey, D.J.; Wormald, M.R.; Serban, H.; Prusiner, S.B.; Kobata, A.; Dwek, R.A.
Glycosylation differences between the normal and pathogenic prion protein isoforms
Proc. Natl. Acad. Sci. USA
96
13044-13049
1999
Mesocricetus auratus
Shibukawa, Y.; Takahashi, M.; Laffont, I.; Honke, K.; Taniguchi, N.
Down-regulation of hydrogen peroxide-induced PKCdelta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells
J. Biol. Chem.
278
3197-3203
2003
Homo sapiens
Taniguchi, N.; Miyoshi, E.; Ko, J.H.; Ikeda, Y.; Ihara, Y.
Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism
Biochim. Biophys. Acta
1455
287-300
1999
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus (Q02527)
Song, E.Y.; Kim, K.A.; Kim, Y.D.; Kwon, D.H.; Lee, H.S.; Kim, C.H.; Chung, T.W.; Byun, S.M.
A simplified procedure for the purification of human N-acetylglucosaminyltransferase-III from human hepatocellular carcinoma tissues
Biotechnol. Lett.
22
201-204
2000
Homo sapiens
-
Ikeda, Y.; Koyota, S.; Ihara, H.; Yamaguchi, Y.; Korekane, H.; Tsuda, T.; Sasai, K.; Taniguchi, N.
Kinetic basis for the donor nucleotide-sugar specificity of beta1,4-N-acetylglucosaminyltransferase III
J. Biochem.
128
609-619
2000
Rattus norvegicus
Guo, H.B.; Jiang, A.L.; Ju, T.Z.; Chen, H.L.
Opposing changes in N-acetylglucosaminyltransferase-V and -III during the cell cycle and all-trans retinoic acid treatment of hepatocarcinoma cell line
Biochim. Biophys. Acta
1495
297-307
2000
Homo sapiens
Song, E.Y.; Kang, S.K.; Lee, Y.C.; Park, Y.G.; Chung, T.H.; Kwon, D.H.; Byun, S.M.; Kim, C.H.
Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2
Cancer Invest.
19
799-807
2001
Homo sapiens
Ikeda, Y.; Taniguchi, N.
Enzymatic properties and biological functions of beta1,4-N-acetylglucosaminyltransferase III
Trends Glycosci. Glycotechnol.
13
167-176
2001
Gallus gallus, Homo sapiens, Rattus norvegicus, Rattus norvegicus (Q02527)
-
Ihara, H.; Ikeda, Y.; Koyota, S.; Endo, T.; Honke, K.; Taniguchi, N.
A catalytically inactive beta1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor
Eur. J. Biochem.
269
193-201
2002
Homo sapiens, Rattus norvegicus
Takamatsu, S.; Inoue, N.; Katsumata, T.; Nakamura, K.; Fujibayashi, Y.; Takeuchi, M.
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures
Biochemistry
44
6343-6349
2005
Homo sapiens
Gu, J.; Zhao, Y.; Isaji, T.; Shibukawa, Y.; Ihara, H.; Takahashi, M.; Ikeda, Y.; Miyoshi, E.; Honke, K.; Taniguchi, N.
beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells
Glycobiology
14
177-186
2004
Rattus norvegicus
Song, E.Y.; Kim, K.S.; Kim, K.A.; Kim, Y.D.; Kwon, D.H.; Byun, S.M.; Kim, H.J.; Chung, T.W.; Choe, Y.K.; Chung, T.W.; Kim, C.H.
Determination of UDP-N-acetylglucosamine:beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III in patients sera with chronic hepatitis and liver cirrhosis using a monoclonal antibody
Glycoconj. J.
19
415-421
2003
Homo sapiens
Jin, X.L.; Liu, H.B.; Zhang, Y.; Wang, B.S.; Chen, H.L.
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma
Glycoconj. J.
20
399-406
2004
Homo sapiens
Takamatsu, S.; Katsumata, T.; Inoue, N.; Watanabe, T.; Fujibayashi, Y.; Takeuchi, M.
Abnormal biantennary sugar chains are expressed in human chorionic gonadotropin produced in the choriocarcinoma cell line, JEG-3
Glycoconj. J.
20
473-481
2004
Homo sapiens
Sasai, K.; Ikeda, Y.; Ihara, H.; Honke, K.; Taniguchi, N.
Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the Golgi apparatus
J. Biol. Chem.
278
25295-25301
2003
Homo sapiens
Chung, T.W.; Kim, K.S.; Kim, C.H.
Reduction of the Gal-alpha1,3-Gal epitope of mouse endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene
Mol. Cells
16
368-376
2003
Homo sapiens
Ferrara, C.; Bruenker, P.; Suter, T.; Moser, S.; Puentener, U.; Umana, P.
Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1,4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II
Biotechnol. Bioeng.
93
851-861
2006
Rattus norvegicus
Shigeta, M.; Shibukawa, Y.; Ihara, H.; Miyoshi, E.; Taniguchi, N.; Gu, J.
beta1,4-N-Acetylglucosaminyltransferase III potentiates beta1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cells
Glycobiology
16
564-571
2006
Rattus norvegicus
Rouwendal, G.J.; Wuhrer, M.; Florack, D.E.; Koeleman, C.A.; Deelder, A.M.; Bakker, H.; Stoopen, G.M.; van Die, I.; Helsper, J.P.; Hokke, C.H.; Bosch, D.
Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III
Glycobiology
17
334-344
2007
Homo sapiens
Iijima, J.; Zhao, Y.; Isaji, T.; Kameyama, A.; Nakaya, S.; Wang, X.; Ihara, H.; Cheng, X.; Nakagawa, T.; Miyoshi, E.; Kondo, A.; Narimatsu, H.; Taniguchi, N.; Gu, J.
Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells. Involvement of E-cadherin-mediated cell adhesion
J. Biol. Chem.
281
13038-13046
2006
Mus musculus
Zhao, Y.; Nakagawa, T.; Itoh, S.; Inamori, K.; Isaji, T.; Kariya, Y.; Kondo, A.; Miyoshi, E.; Miyazaki, K.; Kawasaki, N.; Taniguchi, N.; Gu, J.
N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration
J. Biol. Chem.
281
32122-32130
2006
Homo sapiens
Takahagi, Y.; Fujimura, T.; Miyagawa, S.; Nagashima, H.; Shigehisa, T.; Shirakura, R.; Murakami, H.
Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III
Mol. Reprod. Dev.
71
331-338
2005
Homo sapiens
Li, W.; Takahashi, M.; Shibukawa, Y.; Yokoe, S.; Gu, J.; Miyoshi, E.; Honke, K.; Ikeda, Y.; Taniguchi, N.
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity
Glycobiology
17
655-662
2007
Rattus norvegicus
Chakraborty, A.K.; Pawelek, J.
beta1,6-Branched oligosaccharides regulate melanin content and motility in macrophage-melanoma fusion hybrids
Melanoma Res.
17
9-16
2007
Mus musculus
Frey, A.D.; Karg, S.R.; Kallio, P.T.
Expression of rat beta(1,4)-N-acetylglucosaminyltransferase III in Nicotiana tabacum remodels the plant-specific N-glycosylation
Plant Biotechnol. J.
7
33-48
2009
Rattus norvegicus
Akama, R.; Sato, Y.; Kariya, Y.; Isaji, T.; Fukuda, T.; Lu, L.; Taniguchi, N.; Ozawa, M.; Gu, J.
N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex
Proteomics
8
3221-3228
2008
Homo sapiens
Gu, J.; Isaji, T.; Sato, Y.; Kariya, Y.; Fukuda, T.
Importance of N-glycosylation on alpha5beta1 integrin for its biological functions
Biol. Pharm. Bull.
32
780-785
2009
Homo sapiens
Gu, J.; Taniguchi, N.
Potential of N-glycan in cell adhesion and migration as either a positive or negative regulator
Cell Adh. Migr.
2
243-245
2008
Homo sapiens
Okada, T.; Ihara, H.; Ito, R.; Taniguchi, N.; Ikeda, Y.
Bidirectional N-acetylglucosamine transfer mediated by beta-1,4-N-acetylglucosaminyltransferase III
Glycobiology
19
368-374
2009
Rattus norvegicus
Pinho, S.S.; Reis, C.A.; Paredes, J.; Magalhaes, A.M.; Ferreira, A.C.; Figueiredo, J.; Xiaogang, W.; Carneiro, F.; Gaertner, F.; Seruca, R.
The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin
Hum. Mol. Genet.
18
2599-2608
2009
Homo sapiens
Kariya, Y.; Kato, R.; Itoh, S.; Fukuda, T.; Shibukawa, Y.; Sanzen, N.; Sekiguchi, K.; Wada, Y.; Kawasaki, N.; Gu, J.
N-Glycosylation of laminin-332 regulates its biological functions. A novel function of the bisecting GlcNAc
J. Biol. Chem.
283
33036-33045
2008
Homo sapiens
Sato, Y.; Isaji, T.; Tajiri, M.; Yoshida-Yamamoto, S.; Yoshinaka, T.; Somehara, T.; Fukuda, T.; Wada, Y.; Gu, J.
An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III
J. Biol. Chem.
284
11873-11881
2009
Homo sapiens
Karg, S.R.; Frey, A.D.; Kallio, P.T.
Reduction of N-linked xylose and fucose by expression of rat beta1,4-N-acetylglucosaminyltransferase III in tobacco BY-2 cells depends on Golgi enzyme localization domain and genetic elements used for expression
J. Biotechnol.
146
54-65
2010
Rattus norvegicus
Gu, J.; Sato, Y.; Kariya, Y.; Isaji, T.; Taniguchi, N.; Fukuda, T.
A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions
J. Proteome Res.
8
431-435
2009
Homo sapiens, Mus musculus
Pinho, S.S.; Figueiredo, J.; Cabral, J.; Carvalho, S.; Dourado, J.; Magalhaes, A.; Gaertner, F.; Mendonca, A.M.; Isaji, T.; Gu, J.; Carneiro, F.; Seruca, R.; Taniguchi, N.; Reis, C.A.
E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V
Biochim. Biophys. Acta
1830
2690-2700
2012
Homo sapiens, Homo sapiens (Q09327)
Okada, T.; Ihara, H.; Ito, R.; Nakano, M.; Matsumoto, K.; Yamaguchi, Y.; Taniguchi, N.; Ikeda, Y.
N-Glycosylation engineering of lepidopteran insect cells by the introduction of the beta1,4-N-acetylglucosaminyltransferase III gene
Glycobiology
20
1147-1159
2010
Rattus norvegicus
Xu, Q.; Akama, R.; Isaji, T.; Lu, Y.; Hashimoto, H.; Kariya, Y.; Fukuda, T.; Du, Y.; Gu, J.
Wnt/beta-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: the implications of two mutually exclusive pathways for regulation
J. Biol. Chem.
286
4310-4318
2011
Homo sapiens
Xu, Q.; Isaji, T.; Lu, Y.; Gu, W.; Kondo, M.; Fukuda, T.; Du, Y.; Gu, J.
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines
J. Biol. Chem.
287
16563-16574
2012
Homo sapiens, Mus musculus
Reinke, S.; Bayer, M.; Berger, M.; Blanchard, V.; Hinderlich, S.
Analysis of cell surface N-glycosylation of the human embryonic kidney 293T cell line
J. Carbohydr. Chem.
30
218-232
2011
Homo sapiens
-
Pinho, S.S.; Oliveira, P.; Cabral, J.; Carvalho, S.; Huntsman, D.; Gaertner, F.; Seruca, R.; Reis, C.A.; Oliveira, C.
Loss and recovery of Mgat3 and GnT-III mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions
PLoS ONE
7
e33191
2012
Homo sapiens
Bubka, M.; Link-Lenczowski, P.; Janik, M.; Pochec, E.; Litynska, A.
Overexpression of N-acetylglucosaminyltransferases III and V in human melanoma cells. Implications for MCAM N-glycosylation
Biochimie
103
37-49
2014
Homo sapiens (Q09327), Homo sapiens
Hanashima, S.; Korekane, H.; Taniguchi, N.; Yamaguchi, Y.
Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III
Bioorg. Med. Chem. Lett.
24
4533-4537
2014
Homo sapiens (Q09327)
Lu, J.; Isaji, T.; Im, S.; Fukuda, T.; Kameyama, A.; Gu, J.
Expression of N-acetylglucosaminyltransferase III suppresses alpha2,3-sialylation, and its distinctive functions in cell migration are attributed to alpha2,6-sialylation levels
J. Biol. Chem.
291
5708-5720
2016
Homo sapiens (Q09327), Homo sapiens
Link-Lenczowski, P.; Bubka, M.; Balog, C.I.A.; Koeleman, C.A.M.; Butters, T.D.; Wuhrer, M.; Litynska, A.
The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans
Glycoconj. J.
35
217-231
2018
Homo sapiens (Q09327)
Allam, H.; Johnson, B.P.; Zhang, M.; Lu, Z.; Cannon, M.J.; Abbott, K.L.
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer
J. Biol. Chem.
292
16351-16359
2017
Homo sapiens (Q09327)
Deng, Q.; Yin, N.; Chen, Y.; Shan, N.; Liu, X.; Qi, H.
Downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition
J. Matern. Fetal. Neonatal. Med.
32
2369-2375
2019
Homo sapiens (Q09327), Homo sapiens
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