2.4.1.143: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.143

2.4.1.143

n-glycans

carbohydrate-deficient

complex-type

dyserythropoietic

oligomannose

hempas

schachter

monoantennary

phosphomannomutase

synthesis

Reaction

beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Synonyms

2-beta-N-acetylglucosaminyltransferase, acetylglucosaminyltransferase II, alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase, beta-1,2-N-acetylglucosaminyltransferase II, BmGnTII, EC 2.4.1.51, GlcNAc-T II, GlcNAcT-II, GlcNAcTase-II, GnT II, Gnt II-A, Gnt II-B, GnT-II, GnTII, Mgat2, N-acetylglucosaminyltransferase II, N-acetylglucosaminyltransferase-II, N-acetylglucosaminyltransferases II, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II, TbGnTII, TbGT15, TTV/DEXT1, UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II, UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.143 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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Results	in table
4	Activating Compound
2043	AA Sequence
1	Application
4	CAS Registry Number
14	Cloned(Commentary)
1	Crystallization (Commentary)
34	Disease/ Diagnostics
1	Expression
20	General Information
3	General Stability
17	Inhibitors
16	kcat/KM [mM/s]
5	Ki Value [mM]
35	KM Value [mM]
21	Localization
14	Metals/Ions
8	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
49	Organism
5	Pathway
6	PDB ID
10	pH Optimum
1	pH Range
3	Posttranslational Modification
13	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
47	Reference
57	Source Tissue
6	Specific Activity [micromol/min/mg]
3	Storage Stability
66	Substrates and Products (Substrate)
7	Subunits
54	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Stability [°C]
16	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.143 - alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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alpha-D-Man-(1->6)-[beta-D-GlcNAc(1->2)-alpha-D-Man(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + UDP-GlcNAc

Bombyx mori

A0A451FEC8

i.e. pyridylaminated MGn glycan, an intermediate during N-glycan processing

759523

UDP-alpha-D-GlcNAc + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Homo sapiens

Q10469

760070

UDP-alpha-D-GlcNAc + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[VSG221 protein]

UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[VSG221 protein]

2 entries

UDP-GlcNAc + alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-alpha-D-Man

2 entries

UDP-GlcNAc + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc

UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc

2 entries

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R

UDP + N-acetyl-beta-D-glucosaminyl 1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R

Xenopus laevis

Q7ZZX7

the enzyme catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides

658859

UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetylglucosaminyl-R

UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetylglucosaminyl-R

Rattus norvegicus

essential for biosynthesis of complex N-linked oligosaccharides

644865

additional information

2 entries